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news.Bioengineering solutions provider, DNA2.0 and Newcastle University have formed a research collaboration to develop a protein expression system for Bacillus subtillis.
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As part of the collaboration, DNA2.0 and Newcastle plan to use their synergies in computational design and the development of industrially relevant bacterial strains.
DNA2.0 will also use GeneGPS gene optimization technology to develop enhanced gene synthesis algorithms for the bacterium.
Newcastle’s Centre for Bacterial Cell Biology and School of Computing Science professor Anil Wipat and his team have researched on the synthetic biology applications of B. Subtillis.
Professor Anil Wipat said, "We are thrilled to be able to apply DNA2.0’s experience developing protein expression systems for a wide range of hosts to B. Subtillis."
DNA2.0 cofounder and CEO Jeremy Minshull said professor Wipat’s lab at Newcastle is producing some important research in synthetic biology and DNA2.0 is collaborating with him.
"By combining our patented GeneGPS technology — which has been proven to increase protein expression up to 100-fold — with Newcastle’s deep experience with B. subtillis, I’m confident that we will develop a best-in-class solution for this important bacterium for industrial biotechnology," Minshull added.
The research partners will also develop gene design algorithms.
B. subtillis is a main production host for industrial enzyme manufacturing and an important bacterial workhorse for microbial fermentations.