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news.Novartis reported Phase II data which demonstrated the efficacy of DEB025 (alisporivir) in producing viral elimination in interferon-free regimens (as monotherapy or with ribavirin), in previously untreated patients infected with the hepatitis C virus (HCV) genotypes 2 and 3.
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DEB025 belongs to a new class of drugs called cyclophilin inhibitors and offers an effective treatment option across HCV genotypes, with a high barrier to resistance.
The 12-week trial showed that around 49% of the patients on DEB025 plus ribavirin achieved viral clearance (negative HCV RNA) as early as week six.
One third of patients (32%) receiving DEB025 alone also achieved viral clearance after six weeks.
However, 97% of patients with viral clearance who continued to receive interferon-free DEB025 plus ribavirin maintained this viral clearance up to week 12.
Novartis licensed DEB025 from Debiopharm Group, an independent biopharmaceuticals company based in Switzerland.