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news.Accu-Break Pharmaceuticals has reported the issuance of two patents covering its Accu-Break technologies. The technologies are intended to create pharmaceutical tablets that can be easily divided into precise doses to facilitate titration, dose adjustment and individualized dosing.
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The first patent claims a layered immediate-release (IR) tablet having at least two different active ingredients segregated from each other by a drug-free layer. The innovative tablet design may be used to combine medications in a way that allows them to be administered together in a single tablet, as in traditional fixed-dose combination tablets, but also enables the two medications to be accurately separated if medically indicated simply by splitting the tablet through the drug-free layer.
The second patent also claims divisible tablets, but involves the creation of tablets that contain a half dose of the same active (or combination of the same actives) on each end of the tablet, separated by a drug-free break layer. Division of these tablets through the drug-free break layer would provide an accurate partial dose of the active, useful for titration and dose adjustment.