Advertise With UsAdvertise on our extensive network of industry websites and newsletters.
Get the PBR newsletterSign up to our free email to get all the latest PBR
news.Ablynx has said that the research collaboration which forms part of its license agreement for nanobodies to tumour necrosis factor alpha (TNF-alpha) with Pfizer has been extended for another year.
Subscribe to our email newsletter
Reportedly, Ablynx had signed the research collaboration and license agreement with Pfizer (originally signed with Wyeth Pharmaceuticals) in November 2006, a deal potentially worth $212.5m in past and future milestone payments for commercialisation across multiple indications. In addition, Ablynx is eligible to receive royalties on product sales.
As per the agreement, Pfizer has exclusive rights to develop and commercialise anti-TNF-alpha nanobodies developed under the collaboration. The lead nanobody-based candidate is in a Phase II study in patients with rheumatoid arthritis.
The license agreement includes a research collaboration where Pfizer and Ablynx are working together to discover and develop additional nanobody-based therapeutics against TNF-alpha. TNF-alpha is a key drug target in combating inflammation related disorders such as rheumatoid arthritis, Crohn’s disease, psoriatic arthritis and ankylosing spondylitis.
Edwin Moses, chairman and CEO of Ablynx, said: “We are delighted with this research collaboration extension and the rapid progress made in the partnership with Pfizer.
“We look forward to seeing the lead Nanobody candidate progress through Phase II trials, as well as working towards the goal of advancing additional anti-TNF-alpha Nanobodies towards the clinic. There are now four Nanobodies in clinical trials including Ablynx’s two anti-thrombosis programmes and an anti-RANKL programme.”