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news.Alnylam Pharmaceuticals, an RNAi therapeutics company, has received claims in a second patent application from the Japanese Patent Office (JP Application Number 2006-317758) for the Tuschl II patent series entitled 'RNA Interference Mediating Small RNA Molecules.'
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Alnylam said that in May 2008, the Japanese Patent Office had granted a related set of claims in the Tuschl II patent series (JP 4 095 895).
The Tuschl II patent is exclusively licensed to Alnylam for RNAi therapeutics on a worldwide basis through an agreement with Max Planck Innovation, the licensing agent for the Max Planck Society.
The newly granted patent includes 38 claims broadly covering compositions, methods, uses, and systems for double-stranded RNAs having key structural elements that are recognized as important for the therapeutic activity of siRNAs, including: a double-stranded region formed from two RNA strands with a length of 19-23 nucleotides; at least one 3′-nucleotide overhang at the ends of the double-stranded molecule with a length of 1-3 nucleotides; and, one strand of the RNA molecule consisting of a sequence with less than full complementarity to a target mRNA.
Alnylam’s Intellectual Property (IP) position is comprised of fundamental, chemistry, delivery, and target patents and patent applications that the company believes are necessary for the development and commercialization of RNAi therapeutics. In aggregate, Alnylam owns or has in-licensed over 1,800 active patent cases, of which over 700 have issued or been granted worldwide, and over 300 have issued or been granted in the US, Europe, or Japan.
Barry Greene, president and chief operating officer of Alnylam, said: “We are very pleased with the grant of this second Tuschl II patent application in Japan, which continues to further extend Alnylam’s leadership on intellectual property for RNAi therapeutics. The grant of this new patent broadens the scope of our fundamental patent and patent applications, including those related to the Crooke, Kreutzer-Limmer, Glover, Tuschl I, and Tuschl II patent series.
“Further, we continue to expect that several additional patents owned or licensed exclusively to Alnylam will be awarded, continuing to extend the breadth of our patent portfolio for all RNAi therapeutics.”
Joern Erselius, managing director of Max Planck-Innovation, said: “We are gratified that the Japanese Patent Office has decided to grant these new claims from Tuschl II. The successful worldwide examination of the Tuschl II patent series highlights that this invention is seminal for RNAi, demonstrating the importance of the work performed by Professor Tuschl and other co-inventors at the Max Planck Institute.”