Microsomes are a valuable tool for investigating drugs metabolism (enzyme inhibition, clearance and metabolite identification), as well as for examining in vitro drug-drug interactions. They are made by mechanically homogenising cells such that the endoplasmic reticulum is fragmented, the fractions of which reform into microsomes, which are subsequently collected from the cell remnants via differential centrifugation. During this process, the numerous different phase I cytochrome P450 enzymes (CYPs) are concentrated within the microsomes. The S9 fraction contains microscomes as well as cytosolic phase II metabolism-related enzymes.

With this extensive portfolio of microsomes and S9 fractions, as well as the capability to provide bespoke products, Sera Lab offers researchers the opportunity to match the species, strain and enzyme activity requirements for successful drug metabolism studies.

For further information, please email sales@seralab.co.uk or visit www.seralab.co.uk