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January 22, 2026

Opna Bio’s OPN-2853 secures FDA’s orphan drug status for myelofibrosis

Opna Bio has received the US Food and Drug Administration’s (FDA) orphan drug designation for OPN-2853 (zavabresib), a bromodomain and extra-terminal motif (BET) small molecule inhibitor, to treat myelofibrosis.

Myelofibrosis is a rare blood cancer causing bone marrow scarring, severe fatigue, anaemia, and enlarged spleen. Credit: Nemes Laszlo / Shutterstock.com.