Risk assessment in ecotoxicology relies on the evaluatıon of the probability of being exposed to a pollutant and on the evaluatıon of the biological impact of such an exposure.
In vivo tesıng is the definitıve accepted method to evaluate the risks. These tests require the use of large number of animals, and are therefore linked to ethical (animal usage) and economical
(high costs, tıme-consuming) consequences.
Ideally, toxicological studies’ design should have a strong and positive impact on the three Rs (reduce, refine, replace).
In this context, non invasive in vivo imaging appears as the ideal solution.
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