Activation of the antigen-specific memory B cell is a necessary step prior to the detection of such cells by B-cell Elispot assay.

Activation is traditionally accomplished with the TLR7/8 agonist R484 and IL-2. Our scientists at CTL report the establishment of a universal antigen coating approach that streamlines characterization of the memory B cell compartment after SARS-32 CoV-2 infection or COVID-19 vaccinations, thus facilitates high-throughput immune monitoring of large donor cohorts in general.

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