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B-cells Withstand Cryopreservation While Retaining Functionality

In individuals that have once developed humoral immunity to an infectious or foreign antigen, the antibodies present in their body can mediate instant protection when the antigen re-enters.

Such antigen-specific antibodies can be readily detected in the serum. Long-term humoral immunity is, however, also critically dependent on the ability of memory B-cells to engage in a secondary antibody response upon re-exposure to the antigen.

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