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HCMV Exposure that Serum Antibodies Fail to Identify

It is essential to identify donors that have not been infected with human cytomegalovirus (HCMV) to avoid transmission of HCMV to recipients of blood transfusions or organ transplants.

In the present study, CTL Laboratories tested the reliability of seronegativity as an indicator for the lack of HCMV exposure in healthy human blood donors.

A total of 82 HCMV seronegative individuals were identified and their peripheral blood mononuclear cells (PBMC) were tested in ImmunoSpot assays for the presence of HCMV-specific T-memory and B-memory lymphocytes.

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