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Saturated Bioisosteres of Benzene

“Escape the Flatland” concept has already gained considerable attention in medicinal chemistry. Scientists are looking more and more now for 3D-shaped saturated building blocks. In this context, conformationally rigid bicyclic tetrahydrofurans are intrinsically promising for drug discovery. In continuation of our ongoing program towards novel building blocks for drug discovery, herein we have designed and synthesized a library of saturated mimics of the benzene ring with improved solubility in water.

Our offer:

We offer more than 100 mono– and disubstituted benzene mimics with improved water solubility from stock on a 5-10 g scale:

More details about design and full list of compounds you can find at MedChem Highlights section of Enamine’s website.