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SF5-Containing Building Blocks

The organic chemistry of the pentafluorosulfanyl group (SF5) has been known since the 1950s. As the SF5-group is larger and more lipophilic than the CF3-one, it is often considered as a ‘super-trifluoromethyl group’. Over the past decade, the SF5–containing organic compounds already found great practical application in argochemistry and medicinal chemistry.


  • One of the most electron-withdrawing groups
  • high chemical and thermal stability
  • high lipophilicity

Our offer

> 30 SF5-buiding blocks in gram amounts in stock. Custom synthesis of analogues and compound libraries