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Formulation and Development of Fixed-Dose Combinations

This article is aimed to offer a general review of the fixed-dose combinations (FDC), the manufacturing technologies and their applications, benefits and setbacks, as well as a case study to illustrate the product concept based on the technological platform of Unigel® for FDCs in soft gelatin capsules.

The FDC systems were mainly aimed to increase patient compliance with pharmacological treatments composed of two or more active drugs in a single dosage form in order to decrease the number of doses and prescription problems.

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