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Vertellus Specialties UK Ltd

Supplier of Biocompatible Materials


Vertellus Specialties UK Ltd

Vertellus Biomaterials, is the exclusive supplier of a range of clinically proven biocompatible materials (PC Technology™) which are used to improve the performance of medical devices and for drug delivery.

Coated and uncoated PVC tubing

PC Technology comprises monomers and polymers incorporating phosphorylcholine (PC) for use as components of formulations used to make contact lenses or as coatings to reduce the adverse interaction of the body with medical devices.

These materials have proven drug delivery capability from medical devices.

Biocompatible Materials

The technology has been established in the clinic for over 15 years and there is a great deal of safety and efficacy data available in applications including:

•   Contact lenses (Proclear®, CooperVision)

•   Extra-corporeal blood treatments (Sorin)

•   Wound repair (AMS)

•   Urology(Mediglobe) and

•   Vascular stents (Abbott and Medtronic).

Uniquely, devices incorporating PC enjoy the benefit of three US Food and Drug Administration (FDA) allowed label claims relating to improved comfort (contact lenses), reduced thrombus (coronary guidewires) and reduced biofilm formation.

The phosphorylcholine group carries both positive and negative charges, which results in high polarity and affinity for water, but is overall electrically neutral, which reduces interactions with charged biomolecules. Materials containing PC have been shown to reduce:

•   Irreversible binding and denaturation of proteins

•   Cell adhesion and activation

•   Blood activation and clotting

•   Excessive inflammatory response

•   Bacterial colonisation and biofilm formation

These properties result from the water affinity of PC, which effectively creates a tightly held layer of water around the PC group, making it energetically unfavourable for proteins to displace the water and to become permanently bound to the substrate surface.

PC Materials are hydrogels and have been shown to be capable of absorbing and controlling the subsequent release of a range of drugs.
PC Coated, drug-eluting stents have been marketed for over ten years.

As PC is a bioinert technology, working through this passive mechanism. For example, there is no pharmacological activity and regulatory challenges are lessened.

Vertellus is pleased to discuss any biomaterials-related requirements, particularly those related to drug delivery, with interested parties.

Vertellus Biomaterials
Vertellus Specialties UK Ltd
Unit 3, The Bullpens
Manor Court, Herriard
RG25 2PH
Tel: +44 (0) 1256 381951

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Coating Process Development

We work with our customers through staged phases, typically including the following:

Feasibility study - to develop a prototype coating process and produce samples for evaluation Development programme - to optimise and scale the coating process Technology transfer - embed and validate the coating process in the customer's production facility Commercialisation- regulatory and marketing support In addition to medical applications, PC materials are finding use as treatments…

Speciality Monomers for Contact Lenses

The main monomer produced containing the PC group is MPC (also known as HEMA-PC). This high purity material is made on a multi-ton quantity using a proprietary process. MPC is used in contact lens manufacture and in the production of biocompatible polymer systems. A number of other PC monomers are available on an R&D scale for evaluation purposes.

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Biocompatible Polymers

Vertellus develops coating processes to allow customers to incorporate PC into their products, and offers both off-the-shelf and bespoke biomaterials.

Vertellus supplies a range of PC-polymers, and these materials have been shown to be capable of application to many substrates, including metals, plastics and ceramics. Careful choice of co-monomers allows the production of materials with the desired properties. Polymers may be hydrophilic or hydrophobic and may incorporate active chemical groups for added functionality. Materials Master…
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