Clinical TrialsHuman Trials November 19, 2018 AstraZeneca’s Imfinzi fails to improve OS in Mystic lung cancer trial By PBR Staff Writer The company has reported the final OS results for the phase III Mystic trial, which is a study of Imfinzi monotherapy and the combination of Imfinzi and anti-CTLA4
Clinical TrialsHuman Trials November 15, 2018 Merck’s Keytruda improves overall survival in phase 3 esophageal cancer trial By PBR Staff Writer The phase 3 Keynote-181 study assessing Keytruda as monotherapy in the second-line treatment of advanced or metastatic esophageal or esophagogastric junction carcinoma has achieved a primary endpoint of
Drug DiscoveryResearch & Development November 9, 2018 BioTime signs merger deal with Asterias Biotherapeutics By PBR Staff Writer The merger of BioTime and Asterias Biotherapeutics will enable to create a major cell therapy company. As per terms of the deal, Asterias stockholders will secure 0.71 common
Drug DiscoveryResearch & Development October 22, 2018 Oncology startup TP Therapeutics raises $80m in financing By PBR Staff Writer New investors HBM Healthcare Investments (Cayman) and Nextech Invest also took part in the mezzanine financing, said TP Therapeutics. The new capital secured by the clinical-stage precision oncology
Drug DiscoveryResearch & Development October 19, 2018 Novartis to acquire biopharmaceutical firm Endocyte for $2.1bn By PBR Staff Writer As per terms of the deal, Novartis will purchase all outstanding shares of Endocyte common stock by paying $24 per share. Through using drug conjugation technology, Endocyte will
Clinical TrialsHuman Trials October 12, 2018 BMS, Compugen to evaluate Opdivo-COM701 combo in advanced solid tumors By PBR Staff Writer While Opdivo is a programmed death-1 (PD-1) immune checkpoint inhibitor, COM701 is an investigational anti-PVRIG antibody. Apart from the clinical trial collaboration, Bristol-Myers Squibb has agreed to make
Clinical TrialsHuman Trials October 5, 2018 Lilly, Boehringer’s empagliflozin succeeds in phase III type 1 diabetes trial By PBR Staff Writer Empagliflozin was evaluated for its efficacy, safety and tolerability as an adjunctive to insulin in comparison to placebo in the late-stage clinical program, dubbed EASE. The primary efficacy
Clinical TrialsHuman Trials September 26, 2018 AstraZeneca’s Imfinzi reduces risk of death by 32% in stage III lung cancer By PBR Staff Writer Durvalumab reduced the risk of death by 32% in comparison to standard of care in the late-stage trial. In the durvalumab arm, the median time to death or
Clinical TrialsHuman Trials September 25, 2018 AstraZeneca’s Farxiga succeeds in phase 3 cardiovascular outcomes trial By PBR Staff Writer Farxiga was assessed in a trial, dubbed DECLARE-TIMI 58, in more than 17,000 T2D adult patients having multiple CV risk factors or established CV condition. In the five-year
RegulationMarketing Authorisation September 21, 2018 Mylan, Fujifilm Kyowa get EC nod for Humira biosimilar Hulio By PBR Staff Writer The approval of Hulio is based on adoption of positive opinion by the Committee for Medicinal Products for Human Use (CHMP). The CHMP determined that development program, including