Psychologist awarded grant to research neuroprotection via estrogen

The assistant professor, Noah Sandstrom, has also been granted $10,000 by the National Science Foundation to support work on the modulation of place learning by female sex hormones.

Previous studies have shown that the temporary blockade of blood flow to the brain causes extensive cellular damage within the hippocampus, a brain region critically involved in normal learning and memory processes. The hormone estradiol, a type of estrogen, has been shown to minimize the brain damage that results from such ischemic insults.

Sandstrom is exploring this effect in greater detail, particularly to see if the protective effects of estradiol translate into preservation of learning and memory abilities.

In addition to examining the relationship between neuroprotection and preservation of function, Sandstrom’s team will examine the biological mechanisms through which estradiol exerts its effects on the brain. To determine where the hormone acts to exert its effects, they will administer it to specific brain regions. They will also examine the relationship between the hormone dosage and its effects over time.

The second research award will be used to study estradiol’s effect on learning and memory in rats. Earlier studies have shown that treatment with estradiol can improve learning and memory in rats whose ovaries have been removed. Working with a team of students, Sandstrom is examining the time course over which estradiol modulates learning and memory, as well as the ways in which estradiol interacts with a second hormone, progesterone.