UK-based 4D pharma has commenced patient enrollment for a phase 2 clinical trial to evaluate its single-strain live biotherapeutic candidate Blautix to treat Irritable Bowel Syndrome (IBS).
Glenmark Pharmaceuticals has announced plans to launch a phase 1 trial in solid tumors for its CD38xCD3 bispecific antibody GBR 1342.
Genkyotex’s NOX1/4 inhibitor GKT831 has succeeded in a phase 2 trial in primary biliary cholangitis (PBC), a type of liver disease, by meeting both primary and secondary interim efficacy endpoints.
A clinical trial collaboration has been formed to assess Bristol-Myers Squibb's (BMS) Opdivo in combination with Infinity Pharmaceuticals' IPI-549 in patients with advanced urothelial cancer.
Verona Pharma has completed patient enrollment for a phase 2 trial for its nebulized RPL554 as an add-on to dual therapy using long-acting anti-muscarinic / long-acting beta2-agonists (LAMA/LABA) and triple therapy (LAMA/LABA with an inhaled corticosteroid) in the maintenance treatment of patients with moderate to severe chronic obstructive pulmonary disease (COPD).
ViiV Healthcare has reported positive results for its phase 3 BRIGHTE study of investigational fostemsavir at 48 weeks in heavily treatment-experienced (HTE) patients with HIV-1 infection.
Pfizer has signed a non-exclusive clinical development agreement with Novartis to study one or more combination therapies for the treatment of non-alcoholic steatohepatitis (NASH).
Swiss drugmaker Novartis released additional phase III results of brolucizumab from year two, which reaffirm superiority of the drug over aflibercept in reducing retinal fluid in patients with neovascular age-related macular degeneration (nAMD).
Esperion’s cholesterol drug bempedoic acid has succeeded in a phase 3 trial by achieving its efficacy endpoints and other key measures in patients with atherosclerotic cardiovascular disease (ASCVD) and/or heterozygous familial hypercholesterolemia (HeFH).
Bristol-Myers Squibb (BMS) has dosed the first subject in a clinical trial assessing the safety, pharmacokinetics and pharmacodynamics of BMS-986179, an investigational anti-CD-73 antibody, using Halozyme Therapeutics' Enhanze drug delivery technology.
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