RegulationLawsuits March 26, 2019 Bayer, Janssen settle litigation over blood thinner Xarelto By PBR Staff Writer The companies have reached settlement more than five years after the litigation started with Xarelto. During the period, all six cases related to Xarelto went to trial. Bayer
Clinical TrialsHuman Trials March 22, 2019 GSK’s anti-BCMA antibody-drug conjugate improves ORR in cancer study By PBR Staff Writer The further positive data from the DREAMM-1 study, which is based on results of the pre-specified interim analysis, showed the durability and depth of response of GSK2857916 anti-BCMA
Clinical TrialsHuman Trials March 18, 2019 Study finds widely used heart drug increases risk of sudden cardiac arrest By PBR Staff Writer The findings of the study, called European Sudden Cardiac Arrest network (ESCAPE-NET), were presented at European Heart Rhythm Association (EHRA) 2019. It evaluated if nifedipine and amlodipine –
Drug DiscoveryResearch & Development March 15, 2019 Merck KGaA to use Iktos AI technology across three drug discovery projects By PBR Staff Writer Under The collaboration agreement will enable Merck to use Iktos generative modelling AI technology to facilitate the rapid and cost-effective discovery and design of new compounds. The agreement
Clinical TrialsHuman Trials March 13, 2019 Parkinson’s disease study reveals how cancer drug reduces toxic protein in brain By PBR Staff Writer The research team used a single low dose of Novartis’ leukemia drug Tasigna (nilotinib) in a phase II clinical trial in Parkinson’s disease patients. The researchers claimed that
Drug DiscoveryResearch & Development March 12, 2019 Seres, AstraZeneca to collaborate on microbiome immuno-oncology By PBR Staff Writer According to Seres Therapeutics, the partners will research to assess microbiome-based approaches as a predictor for which cancer immunotherapies get the best response from patients. In addition, the
Drug DiscoveryResearch & Development March 8, 2019 GTx, Oncternal Therapeutics sign merger deal to create new clinical-stage oncology firm By PBR Staff Writer Oncternal Therapeutics will be the name of the combined company, which will engage in the development of potential first-in-class therapeutic candidates for cancers. As per terms of the
Clinical TrialsHuman Trials March 6, 2019 Novo Nordisk’s Ozempic meets primary endpoint in Sustain 9 diabetes trial By PBR Staff Writer The 30-week long trial, dubbed Sustain 9, assessed the efficacy and safety of Ozempic injection 1.0 mg in combination with the SGLT-2 inhibitors against placebo. The drug was
Clinical TrialsHuman Trials March 5, 2019 Verona’s ensifentrine DPI formulation succeeds in part 1 of COPD trial By PBR Staff Writer Also known as RPL554, ensifentrine, is being investigated as an inhaled dual inhibitor of the phosphodiesterase 3 and 4 enzymes and is designed to have bronchodilator and anti-inflammatory
Clinical TrialsHuman Trials March 5, 2019 Shield Therapeutics’ Feraccru meets endpoints in anaemia trial By PBR Staff Writer The phase IIIb trial compared Feraccru against Ferinject in 242 inflammatory bowel disease (IBD) patients whose iron deficiency anaemia (IDA) and haemoglobin (Hb) measurements are as low as