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WHITE PAPERS

B-cells Withstand Cryopreservation While Retaining Functionality

Multi-Colour NK Cell-Mediated Cytotoxicity Detection Using Fluorescence

User Versus Software-Dependent Variability of ELISPOT Counts

ELISPOT Assays Provide Reproducible Results Among Different Laboratories

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PRODUCTS & SERVICES

Analysis of Morphometric Bioassays with CTL’s BioSpot® Image Analysis Platform

Assay Standardisation for Monitoring of Cell Mediated Immunity

ELISA, Multiplex, and Flow Cytometry Testing

ELISPOT ImmunoSpot® Analysers

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LATEST PRESS RELEASES

August 26, 2011

Alliance Selects SCM for Sterile Product Supply

SPECIALITY pharmaceutical company Alliance Pharma has awarded a commercial supply contract for three of its products to sterile manufacturing expert...

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CTL Laboratories

Cellular Technology Limited (CTL) is a privately held biotechnology company that built its reputation as a global leader in the enzyme-linked immunospot (ELISPOT) field over the past two decades by establishing the ELISPOT instrumentation and scientific principles that have helped to define the parameters of ELISPOT research for monitoring of cell-mediated immunity.

Headquartered in Shaker Heights, OH, the company focuses on high-throughput ELISPOT assays, multiplex cytokine bead arrays (CBA), flow cytometry (such as phenotyping and multimer readouts), and BrdU proliferation assays.

CTL is uniquely capable of developing, qualifying and validating assays tailored to its clients’ specific needs in its good laboratory practice (GLP) compliant and Clinical Laboratory Improvement Amendments (CLIA) certified laboratory.

Contact

Cellular Technology Limited
20521 Chagrin Boulevard
Shaker Heights
OH 44122-5350
US

Phone: +1 216 791 5084
Fax: +1 216 791 8814
Email: info@immunospot.com
Website: www.immunospot.com

Analysis of Morphometric Bioassays with CTL’s BioSpot® Image Analysis Platform

Objective, scientifically validated counting algorithms ensure accurate results for yeast viability analysis, natural killer (NK) assays, viral plaque assays, clonogenic and genotoxicity assays, and bacterial colony counting. In recent years, Cellular Technology Limited (CTL) has further customised and optimised its instruments, introducing the BioSpot® Analysis Platform for various applications in the biotechnology and pharmaceutical industries…

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Assay Standardisation for Monitoring of Cell Mediated Immunity

Access up to 2,000 vials of cryopreserved peripheral blood mononuclear cells (PBMC) from a single donor from CTL's extensive library of established antigen reactivity and high-resolution (HR) Human leukocyte antigen (HLA) typed healthy donors (more than 100) to enable standardisation of your cell-based assays. Supporting cell-based assay standardisation CTL provides comprehensive standardisation packages for cellular assays,…

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ELISA, Multiplex, and Flow Cytometry Testing

CTL’s enzyme-linked immunospot (ELISPOT) assay expertise is complemented by its ELISA testing, multiplex cytometric bead array (CBA) and fluorescence-activated cell sorting (FACS) services. ELISA testing can be used to extract additional information on the production of antibodies or other cytokines from the same sample without requiring the use of additional blood draws. Similarly, flow cytometry can…

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ELISPOT ImmunoSpot® Analysers

CTL's enzyme-linked immunospot (ELISPOT) assays are an effective readout system for cytokine-based immune monitoring and standardsation strategies. In addition to its Clinical Laboratory Improvement Amendments (CLIA) certified, good laboratory practice (GLP) compliant laboratory operations in which the company performs ELISPOT assays for its clients, CTL specialises in developing and manufacturing image-based analysis, high-throughput 21 CFR Part 11…

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High-Throughput Immune Contract Laboratory Services

A four to five-week turnaround time for up to 1,000 subjects assayed for antigen-specific cytokine responses allows you to significantly accelerate immune monitoring of patient samples. CTL has many years of experience in performing contracted laboratory services. Its laboratory complies with Clinical Laboratory Improvement Amendments (CLIA) and US Food and Drug Administration (FDA) regulations, including…

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Monitoring of Cell Mediated Immunity Focusing on T and B-Cells

CTL's enzyme-linked immunospot (ELISPOT) assays are effective readout systems for cytokine-based immune monitoring and standardisation strategies. ELISPOT assays and the related multiplex FluoroSpot technology are ideal for measurement of per-cell antigen-specific cytokine production and direct ex-vivo cytotoxicity assays. T-cell functional avidity studies and epitope mapping, and B-cell ELISPOT assays for determining the class or subclass of…

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Specimen Management

CTL’s specimen management department is solely dedicated to monitoring pre-clinical and clinical samples from receipt to disposition. The company's thorough quality control measures ensure proper specimen handling and accurate data management. The movement of every specimen is tracked meticulously until CTL receives disposition instructions from the sponsor/client. CTL is a member of the International Society…

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Specimen Processing

CTL provides laboratory services for processing and cryopreserving both pre-clinical and clinical specimens. Its scientific team has a wealth of experience in processing whole blood to obtain peripheral blood mononuclear cells (PBMC) or separate cell populations such as CD4, CD8, natural killer (NK) cells and monocytes. CTL also has experience in the processing of solid…

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Contracted ELISPOT Testing for Immune Monitoring

CTL has years of experience in contracted research. Many pharmaceutical and biotechnology companies have entrusted CTL with evaluating cell-mediated immunity (CMI) to their vaccines, drugs, and biologic products using the enzyme-linked immunospot (ELISPOT) technique. Are you using the appropriate readout system for evaluating your test subject response? CTL's greatest strength lies in its high-throughput T-cell monitoring…

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Affinity Tag Coating Enables Reliable Detection of Antigen-Specific B Cells in Immunospot Assays

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Detection of Antigen-Specific T Cell Lineages and Effector Functions Based on Secretory Signature

T cells not only protect us from infectious diseases and cancer, but are also involved in transplant rejection, autoimmune diseases, and allergies. Each of these immunologic processes share a common link in which antigen-specific T cells undergo expansion, with some of the resulting progeny differentiating into memory cells.

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Detecting Clonally Expanded, Stem Cell-Like Melanoma-Antigen Specific CD8 Memory Cells

CTL used four-colour ImmunoSpot® assays, in conjunction with peptide pools that cover the sequence of tyrosinase (Tyr), melanoma-associated antigen A3 (MAGE-A3), melanocyte antigen/melanoma antigen recognised by T-cells 1 (Melan-A/ MART-1), glycoprotein 100 (gp100) and New York esophageal squamous cell carcinoma-1 (NY-ESO-1) to characterise the melanoma antigen (MA)-specific CD8 + cell repertoire in PBMC of 40 healthy human donors (HD).

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Detection of Antigen-Specific T-Cell Lineages and Effector Functions

T-cells not only protect us from infectious diseases and cancer, but are involved in transplant rejection, autoimmune diseases and allergies.

DOWNLOAD WHITEPAPER

HCMV Exposure that Serum Antibodies Fail to Identify

It is essential to identify donors that have not been infected with human cytomegalovirus (HCMV) to avoid transmission of HCMV to recipients of blood transfusions or organ transplants.

DOWNLOAD WHITEPAPER

B-cells Withstand Cryopreservation While Retaining Functionality

In individuals that have once developed humoral immunity to an infectious or foreign antigen, the antibodies present in their body can mediate instant protection when the antigen re-enters.

DOWNLOAD WHITEPAPER

Multi-Colour NK Cell-Mediated Cytotoxicity Detection Using Fluorescence

A role of effector immune cells such as CD8+ cells and natural killer (NK) cells is to identify and lyse target cells.

DOWNLOAD WHITEPAPER

User Versus Software-Dependent Variability of ELISPOT Counts

In each human donor’s peripheral blood mononuclear cell (PBMC), there is a defined number of T-cells specific for any given antigen. A major goal of immune monitoring with enzyme-linked immunospot (ELISPOT) is to measure this number accurately and reproducibly between different laboratories.

DOWNLOAD WHITEPAPER

ELISPOT Assays Provide Reproducible Results Among Different Laboratories

Measurements of antibodies in bodily fluids have provided robust and reproducible results for decades and such assays have been validated for monitoring of B-cell immunity.

DOWNLOAD WHITEPAPER

How Frequently are Predicted Peptides Actually Recognised by CD8 Cells?

Detection of antigen-specific CD8 cells relies on the use of peptides that can bind to human leukocyte antigen (HLA) Class I molecules.

DOWNLOAD WHITEPAPER

Four-Colour B-Cell ELISPOT Assay for Detection of all Four Human IgG Subclasses

ELISPOT assays are a key research tool for enumerating antigen-specific B cells.

DOWNLOAD WHITEPAPER

Publications by Theme

For more than 15 years, Professor Lehmann and the team of scientists working with him have been focused on establishing the scientific foundations of enzyme-linked immunospot (ELISPOT) assays and to test the utility of the technology in various fields of T-cell diagnostics.

DOWNLOAD WHITEPAPER

Characterisation of the CMV-Specific CD4 Cell Response

When most humans become infected with human cytomegalovirus (HCMV), the immune system controls the infection, but the virus typically persists and can reactivate in states of immunodeficiency.

DOWNLOAD WHITEPAPER

Contract Immune Monitoring and Research

Establishing new bioanalytical laboratory assays requires a major investment of effort and capital. Would you like to save both time and money? Let CTL's team of experts handle the details for you.

DOWNLOAD WHITEPAPER

Alliance Selects SCM for Sterile Product Supply

SPECIALITY pharmaceutical company Alliance Pharma has awarded a commercial supply contract for three of its products to sterile manufacturing expert...

26th August 2011

TVA™ – Non-Radioactive NK/ADCC Assessment

Traditionally, natural killer (NK) cell-mediated lysis of K562 tumour cells required laborious, time-consuming, radioactive chromium release assays (CRA). But no...

9th February 2016

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Top Products from CTL Laboratories

Affinity Tag Coating Enables Reliable Detection of Antigen-Specific B Cells in Immunospot Assays

Detection of Antigen-Specific T Cell Lineages and Effector Functions Based on Secretory Signature

Detecting Clonally Expanded, Stem Cell-Like Melanoma-Antigen Specific CD8 Memory Cells

Detection of Antigen-Specific T-Cell Lineages and Effector Functions

T-cells not only protect us from infectious diseases and cancer, but are involved in transplant rejection, autoimmune diseases and allergies.

HCMV Exposure that Serum Antibodies Fail to Identify

It is essential to identify donors that have not been infected with human cytomegalovirus (HCMV) to avoid transmission of HCMV to recipients of blood transfusions or organ transplants.

B-cells Withstand Cryopreservation While Retaining Functionality

In individuals that have once developed humoral immunity to an infectious or foreign antigen, the antibodies present in their body can mediate instant protection when the antigen re-enters.

Multi-Colour NK Cell-Mediated Cytotoxicity Detection Using Fluorescence

A role of effector immune cells such as CD8+ cells and natural killer (NK) cells is to identify and lyse target cells.

User Versus Software-Dependent Variability of ELISPOT Counts

In each human donor’s peripheral blood mononuclear cell (PBMC), there is a defined number of T-cells specific for any given antigen. A major goal of immune monitoring with enzyme-linked immunospot (ELISPOT) is to measure this number accurately and reproducibly between different laboratories.

ELISPOT Assays Provide Reproducible Results Among Different Laboratories

Measurements of antibodies in bodily fluids have provided robust and reproducible results for decades and such assays have been validated for monitoring of B-cell immunity.

How Frequently are Predicted Peptides Actually Recognised by CD8 Cells?

Detection of antigen-specific CD8 cells relies on the use of peptides that can bind to human leukocyte antigen (HLA) Class I molecules.

Four-Colour B-Cell ELISPOT Assay for Detection of all Four Human IgG Subclasses

ELISPOT assays are a key research tool for enumerating antigen-specific B cells.

Publications by Theme

For more than 15 years, Professor Lehmann and the team of scientists working with him have been focused on establishing the scientific foundations of enzyme-linked immunospot (ELISPOT) assays and to test the utility of the technology in various fields of T-cell diagnostics.

Characterisation of the CMV-Specific CD4 Cell Response

When most humans become infected with human cytomegalovirus (HCMV), the immune system controls the infection, but the virus typically persists and can reactivate in states of immunodeficiency.

Contract Immune Monitoring and Research

Establishing new bioanalytical laboratory assays requires a major investment of effort and capital. Would you like to save both time and money? Let CTL's team of experts handle the details for you.

Contact CTL Laboratories

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