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Particle Size and Shape Analysis, Zeta Potential and NIR-Chemical Imaging.

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WHITE PAPERS
12 Key Considerations When Purchasing a Rheometer
Going with the Flow: Malvern Instruments’ Basic Introduction to Rheology
Malvern Instruments Shares its Buyer’s Guide to Protein Stability Measurement Platforms
Addressing the Needs of Drug Discovery with the MicroCal PEAQ-ITC Instruments
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PRODUCTS & SERVICES
MicroCal PEAQ-DSC Manual
MicroCal PEAQ-DSC Automated by Malvern Instruments
MicroCal PEAQ-ITC
MicroCal PEAQ-ITC Automated
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LATEST PRESS RELEASES
October 29, 2019

Malvern Panalytical to Host Ore and Minerals Analysis (OMA) Worldwide Workshops

Throughout the year Malvern Panalytical organizes multiple OMA workshops all over the world. During these free-of-charge seminars, dedicated to the...
pharmacuetical business review
October 4, 2019

Global Standards Developer ASTM International Schedules Board Meeting and Events

ASTM International, one of the world’s leading standards developers, will be holding its board meeting and related events in Boston,...
pharmacuetical business review
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LATEST VIDEOS

Malvern’s Video Explores: What Is Differential Scanning Calorimetry (DSC)?

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Malvern Panalytical

Malvern Panalytical technologies are used by scientists and engineers in a wide range of industries and organizations to solve the challenges associated with maximizing productivity, developing better quality products and getting them to market faster.

Our mission is to create superior, customer-focused solutions and services to deliver tangible economic impact through chemical, physical and structural analysis of materials.

Underpinned by extensive industry knowledge and technical and applications expertise, Malvern Panalytical instruments helps users better understand a wide variety of materials, from proteins and polymers to metals and building materials.

Our technologies enable the measurement of parameters such as particle size, shape and zeta potential, biomolecular interactions and stability, rheological properties, elemental concentrations and crystallographic structure. Highly reliable and robust characterization of these properties is fundamental to predicting how a product will behave during use, to optimizing its performance and achieving manufacturing excellence.

Markets Served

Malvern Panalytical’s products and solutions for discovery, research and development (R&D), process control and product quality assurance are sold primarily into the pharmaceutical, food, bio, metals, mining, minerals, chemicals, petrochemicals and advanced materials sectors, which include many academic and government research facilities worldwide.

Company Background

Malvern Panalytical was formed by a merger of the businesses Malvern Instruments (Malvern, UK) and PANalytical, including ASD and Claisse (Almelo, the Netherlands) on 1 January 2017. The new entity employs more than 2,000 people worldwide.

With R&D and manufacturing sites in North America, Europe and China, as well as a global sales and service presence, Malvern Panalytical provides unrivalled levels of customer support.

Malvern Panalytical is a leader in the materials characterization market, developing expert analytical solutions that deliver superior actionable insight.

To visit the Malvern Panalytical website click here:
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Top Products from Malvern Panalytical


Epsilon Xflow

Morphologi range

Epsilon 1
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MicroCal PEAQ-DSC Manual

Gold standard protein stability analysis for research applications

The MicroCal PEAQ-DSC system provides highly sensitive, easy-to-use microcalorimetry that helps reduce the time and cost associated with stability testing and comparability analysis. The MicroCal PEAQ-DSC is a manual instrument with a cleaning device, which can be upgraded to an automated version upon request.Data generated by the MicroCal PEAQ-DSC provides critical guidance for biopharmaceutical development…
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MicroCal PEAQ-DSC Automated by Malvern Instruments

Gold standard protein stability analysis for the regulated environment

The MicroCal PEAQ-DSC Automated system delivers high throughput, highly sensitive protein stability analysis with low sample consumption, in an automated, integrated platform for increased productivity. All cell filling and cleaning functions are fully automated for walk-away operation.Data generated by the MicroCal PEAQ-DSC Automated provide critical guidance for biopharmaceutical development in protein engineering, (pre)formulation development, process…
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MicroCal PEAQ-ITC

High sensitivity measurement of all binding parameters.

The MicroCal PEAQ-ITC is a highly sensitive, low volume isothermal titration calorimeter for the label-free in solution study of biomolecular interactions. It delivers direct measurement of all binding parameters in a single experiment and can analyze weak to high affinity binders, using as little as 10µg sample. Semi-automated maintenance minimizes operator intervention and the system…
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MicroCal PEAQ-ITC Automated

High productivity measurement of multiple binding parameters.

The MicroCal PEAQ-ITC Automated is a configurable, low volume, highly sensitive isothermal titration calorimeter which offers the convenience of unattended operation. It delivers direct, label-free in solution measurement of all binding parameters in a single experiment. Applications include characterizing molecular interactions of small molecules, proteins, antibodies, nucleic acids, lipids and other biomolecules. It can also…
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NanoSight

The Malvern NanoSight range of instruments utilises Nanoparticle Tracking Analysis (NTA) to characterise nanoparticles.

The Malvern Panalytical NanoSight range of instruments utilizes Nanoparticle Tracking Analysis (NTA) to characterize nanoparticles from 0.01 - 1 µm* in solution. Each particle is individually but simultaneously analyzed by direct observation and measurement of diffusion events. This particle-by-particle methodology produces high resolution results for nanoparticle size distribution and concentration, while visual validation provides users…
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OMNISEC RESOLVE

Combined pump, degasser, autosampler and column oven, for high quality GPC/SEC and accurate molecular weight measurement.

OMNISEC RESOLVE combines with OMNISEC REVEAL to form a complete OMNISEC GPC/SEC solution for the measurement of absolute molecular weight, intrinsic viscosity and other parameters. It combines an integrated pump, degasser, autosampler and column oven in a single advanced separations unit. Discover more about OMNISEC RESOLVE, and other Malvern Instruments.
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OMNISEC REVEAL

The ultimate in integrated advanced detection for GPC/SEC.

Molecular weight, intrinsic viscosity and numerous other parameters can be measured with OMNISEC REVEAL, the world's most advanced integrated GPC/SEC multi-detector available.It can be added to any existing conventional GPC/SEC system or used in conjunction with OMNISEC RESOLVE to form a complete GPC/SEC solution, to offer comprehensive molecular characterization of synthetic and natural polymers, as…
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OmniSEC Software

Powerful, agile, easy to use GPC/SEC software for instrument control, data acquisition, analysis and reporting.

OmniSEC software is an integrated solution for the advanced analysis of proteins and polymers by GPC/SEC, and is at the heart of all Viscotek systems and detectors. Selectable "protein" or "polymer" user interfaces with simplified work flows improve productivity and help you to maximize the information and efficiency of your experiments. Simply load your samples…
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Zetasizer Helix

Characterize secondary and tertiary structure to develop mechanistic insight into oligomerization and aggregation.

The Zetasizer Helix delivers structural information at the molecular level, providing mechanistic insight into the formation of oligomers, unfolding, and aggregation processes of biopharmaceuticals.  Discover more about the ZETASIZER HELIX, and other Malvern Instruments.
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Zetasizer

Zetasizer measures particle and molecule size using dynamic light scattering, zeta potential and electrophoretic mobility.

It is the world's most widely used system for nanoparticle, colloid and protein size, zeta potential and molecular weight measurements.For more information click here. 
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Zetasizer WT

The Zetasizer WT is a fully automated system that delivers lab quality on-line zeta potential measurements. This enables real-time monitoring of flocculation process performance and efficient charge neutralization. On-line charge measurements you can trust are finally here!

Click here for more information.
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Epsilon 4 Range

Built on the experience and success of the proven Epsilon 3 range of XRF spectrometers, the Epsilon 4 is a multi-functional benchtop XRF analyzer for any industry segment needing elemental analysis from fluorine (F) to americium (Am) in areas from R&D through to process control. Combining the latest excitation and detection technologies with mature software…
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Epsilon 1

The Epsilon 1 is a fully integrated energy dispersive XRF analyzer consisting of a spectrometer, built-in computer, touch screen and analysis software. Powered by the latest advances in excitation and detection technology the Epsilon 1 is a star performer in the low-cost benchtop instrument class. Epsilon 1 produces fast, cost-effective, precise and accurate data with…
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Morphologi range

Morphological imaging is fast becoming an essential technology in the laboratory toolkit for particle characterization.  The Morphologi 4 is a fully automated static image analysis system which provides a complete detailed description of the morphological properties of particulate materials.  The Morphologi 4-ID combines the same automated static image analysis with Raman spectroscopy in a single,…
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Epsilon Xflow

Online liquid analysis with the Epsilon Xflow gives the solution for fast and accurate control of your process parameters. Increased regulations and quality specifications drive the need for a continue process flow. The Epsilon Xflow enables real-time insight to manage your production processes more efficient and reduce operational costs. • Simultaneous multi-element analysis • Real-time…
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Characterisation of Liposomes by Complementary Techniques

Characterisation of Liposomes by Complementary Techniques

Liposomes have been attractive delivery systems for decades due to their composition of natural biological lipids and structural resemblance to cell membranes suggesting metabolic compatibility, low toxicity, overall expectations of biocompatibility and lack of a strong immune response.

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Analytical Tools for Comprehensive Characterisation of Li-ion Batteries

Analytical Tools for Comprehensive Characterisation of Li-ion Batteries

The increased demand for portable electronic devices, including mobile phones, laptops and new ‘wearables’, has required advances in battery technology to provide a low-cost, lightweight, long-lasting and stable power source.

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Improved component resolution with Multi- Angle DLS (MADLS)

Improved component resolution with Multi- Angle DLS (MADLS)

There are three advantages that can be derived from the introduction of multiangle dynamic light scattering (MADLS) in the new Zetasizer Ultra system: Improved component sensitivity within mixtures, improved resolution of near-in-size components (from 3:1 to 2:1) and conversion of the transformed number weighted size distribution into particle concentration.

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Using XRD to Cut CO2

Using XRD to Cut CO2

The reduction of CO2 emissions is a major task for the cement industry in the 21st century. This can be achieved by using modern production techniques, optimisation of the burning process, fuel substitutions, alternative clinker compositions or by the production of blended cements with different additives.

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Comparing multi-detector GPC and APC for polyalphaolefin analysis

Comparing multi-detector GPC and APC for polyalphaolefin analysis

Polyalfaolefins (PAO) are low molecular weight hydrocarbons, used in a number of lubricant applications.

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Early Detection of Oak Wilt Disease in Quercus ssp: A Hyperspectral Approach

Early Detection of Oak Wilt Disease in Quercus ssp: A Hyperspectral Approach

Initial work has begun on a long-term study of the application of spectroradiometric techniques to spectral discrimination of oak wilt disease in Quercus woodlands of central Texas.

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Pushing the Limits of Dynamic Light Scattering

Pushing the Limits of Dynamic Light Scattering

Dynamic Light Scattering (DLS) allows the hydrodynamic size of particles in dispersion to be measured by quantifying their diffusive motion.

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Confirming the Pharmaceutical Equivalence of Oral Solid Dose Products

Confirming the Pharmaceutical Equivalence of Oral Solid Dose Products

According to the US Food and Drug Administration (FDA) definition, a generic drug is a product that is comparable to a reference listed drug (RLD) in dosage form, strength, route of administration, quality, performance characteristics and intended use.

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ASTM C114-15 Compliance for Cement-Fused Beads in Ten Minutes

ASTM C114-15 Compliance for Cement-Fused Beads in Ten Minutes

X-ray fluorescence spectroscopy (XRF) has an important and well-established analytical role within the cement industry. It is used extensively for production and quality control for the elemental analysis of raw materials, alternative fuels and finished produces.

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XRF In the Hands of Scientists

XRF In the Hands of Scientists

Looking for a flexible, yet simple-to-use, analytical instrument for research and education?

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EPSILON 1 – Focus on the Details to Capture the Bigger Picture

EPSILON 1 – Focus on the Details to Capture the Bigger Picture

The EPSILON 1 X-ray fluorescence spectrometer is an idea analytical solution for flexible and precise analysis of small objects or small inclusions in rocks, electronic appliances, toys, jewellery or finished products.

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EPSILON 1 – Small and Powerful

EPSILON 1 – Small and Powerful

The Epsilon 1 X-ray fluorescence (XRF) spectrometer is the ideal analytical solution. It is capable of simple element identification and quantification up to more sophisticated analysis.

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Glass Disks and XRF Analysis

Glass Disks and XRF Analysis

Fusion is a proven and reliable technique to prepare samples of X-ray fluorescence (XRF) analysis, but many laboratory technicians still struggle to obtain accurate and reproducible results with this method.

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Analysis of Ultra-Low Sulphur Fuels

Analysis of Ultra-Low Sulphur Fuels

Environmental regulations set the maximum permitted sulphur levels in car fuels at 10mg/kg. Several different X-ray fluorescence (XRF) technologies test methods are available for analysing the concentration.

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Combating Counterfeit Drugs

Combating Counterfeit Drugs

Compared with other forms of counterfeiting, the production of fake medicines almost certainly has the greatest potential for harming human health. 

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Fast Toothpaste Identification by Fingerprint

Fast Toothpaste Identification by Fingerprint

This application note shows that the Epsilon 4 is a high-performance benchtop energy dispersive X-ray fluorescence (XRD) spectrometer that is capable of identifying small differences in materials.

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Reducing the Cost of Cement Production

Reducing the Cost of Cement Production

Two years ago, the Vulcan Materials Company upgraded its cement finishing circuit by installing an advanced process control (APC) solution from Pavilion Technologies and real-time particle size analysis from Malvern Panalytical.

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Adaptive Correlation: Better DLS Data with Less Time and Effort

Adaptive Correlation: Better DLS Data with Less Time and Effort

While being able to measure particles of below 1nm size, dynamic light scattering (DLS) is preferentially sensitive to larger particles due to the sixth-power relationship between particle radius and scattering intensity.

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Use of NanoSight Sample Assistant for Characterisation of Exosomes

Use of NanoSight Sample Assistant for Characterisation of Exosomes

Nanosized plasma membrane vesicles secreted by cells into bodily fluids are known to have an important role in intracellular communication.

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NIR and Dairy

NIR and Dairy

Malvern Panalytical's ASD optical spectrometry instruments have the added value of being portable and with optimal signal-to-noise design for faster measurements, and covering a wide spectral range of 350nm to 2,500nm for a variety of chemical and properties detection possibilities.

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Characterising the Size and Concentration of Lipsomes

Characterising the Size and Concentration of Lipsomes

Liposomes are nowadays frequently used as drug delivery systems, and as such require that they are well characterised for manufacturing and batch release. 

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Measuring the Concentration of AAV with MADLS

Measuring the Concentration of AAV with MADLS

For virus development and production, it is important to know the virus concentration at different stages of the process to optimise the clone used, as well as production yields. 

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Pharmaceutical Challenges Aided by an X-Ray Diffraction System

Pharmaceutical Challenges Aided by an X-Ray Diffraction System

This white paper explores a number of ways that today's modern, laboratory-based powder X-ray diffraction (PXRD) instrumentation and advanced software can greatly assist pharmaceutical scientists in their quest to develop high-quality, stable products and accelerate their speed-to-market.

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Quick and Flexible Elemental Screening with Omnian

Quick and Flexible Elemental Screening with Omnian

Developed for Malvern Panalytical's high-end X-ray fluorescence (XRF) spectrometers, Omnian is also available for the Epsilon 4 EDXRF benchtop systems.

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Getting Acquainted with the Principles

Getting Acquainted with the Principles

This booklet gives a general introduction to X-ray fluorescence (XRF) spectrometry and XRF analysis. It explains simply how a spectrometer works and how XRF analysis is done.

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Analysis of Major and Minor Elements in Cement Pressed Powders

Analysis of Major and Minor Elements in Cement Pressed Powders

This application note shows that the Epsilon 4 (a high-performance energy dispersive X-ray fluorescence spectrometer) is capable of analysing major and minor elements in cement samples. 

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Malvern: Understanding and minimizing polycaprolactone degradation during processing using multi-detector GPC and rheology

Malvern: Understanding and minimizing polycaprolactone degradation during processing using multi-detector GPC and rheology

Measuring degradation related changes in molecular weight and rheology during polycaprolactone processing

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How Malvern Panalytical helped GSK India optimize their manufacturing process using

How Malvern Panalytical helped GSK India optimize their manufacturing process using

GSK India is headquartered at Worli, Mumbai with the manufacturing unit being located at Nashik. A second manufacturing facility at Vemgal, Karnataka is due to be completed in 2018.

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Malvern: High sensitivity gel permeation chromatography for agrochemical analysis

Malvern: High sensitivity gel permeation chromatography for agrochemical analysis

Exploring why Syngenta opted for an OMNISEC system

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Malvern: Measuring the rheology of thermoplastic polymer melts

Malvern: Measuring the rheology of thermoplastic polymer melts

Using rotational and capillary rheometry to characterize polymer melts

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Malvern: Optimizing metal powders for additive manufacturing

Malvern: Optimizing metal powders for additive manufacturing

Exploring the impact of particle morphology and powder flowability.

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Malvern:Establishing an analytical toolkit for the optimization of Li-ion battery electrode manufacturing

Malvern:Establishing an analytical toolkit for the optimization of Li-ion battery electrode manufacturing

The electrodes used in Li-ion batteries have a defining influence on their electrochemical performance and are typically manufactured by coating a metal foil substrate with a multicomponent slurry made up of active electrode particles and conductive additives suspended in a binder solution.

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Understanding Yield Stress Measurements

Understanding Yield Stress Measurements

The yield stress characteristic is a property associated with numerous types of complex fluids - whereby the material does not flow unless the applied stress exceeds a certain value. To read more, click here.

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Understanding the true cost of projects

Understanding the true cost of projects

Choosing the right approach for implementing on-line particle sizing. To read more, click here

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Top tips for avoiding particle sizing failures with your laser diffraction method

Top tips for avoiding particle sizing failures with your laser diffraction method

Particle size defines the performance of a wide range of different products, including cement, paints, inks, metal powders, cosmetics, foods and drinks. Measuring relevant particle size data is therefore essential in many industries, with laser diffraction usually the technique of choice. Fast, highly automated and suitable for measurement across a broad size range, 0.01 to 3500 microns, modern laser diffraction systems have reduced particle sizing to a matter of sample loading and push button operation, providing that a suitable method is in place.

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Analytical characterisation of mouthfeel in chocolate

Analytical characterisation of mouthfeel in chocolate

The particle size and rheology of the chocolate are critical factors in determining and predicting mouthfeel.

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Biophysical application of calorimetric methods to protein misfolding and aggregation examinations

Biophysical application of calorimetric methods to protein misfolding and aggregation examinations

Unfolded proteins fold into thermodynamically-favorable native structures under the correct physiological conditions for gain of function (Figure 1) [1-4]. The burial of hydrophobic regions in a protein's interior, along with the exposure of hydrophilic residues to aqueous solutions stabilizes native structures and ensures solubility. Active native proteins perform their biological functions through highly regulated intermolecular interactions with their binding partners, under thermodynamic control.

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Malvern Instruments: Assessing Fuel Filter Efficiency using Online Laser Diffraction

Malvern Instruments: Assessing Fuel Filter Efficiency using Online Laser Diffraction

Meeting requirements for ISO16332: Standard method for evaluating fuel/water separation efficiency in diesel engines.

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Top 10 Factors to Consider When Selecting a Dynamic Light Scattering (DLS) Instrument

Top 10 Factors to Consider When Selecting a Dynamic Light Scattering (DLS) Instrument

The physical components and features of a dynamic light scattering (DLS) instrument along with the instrument's technical specifications are obviously important considerations when purchasing a new system.

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Malvern Instruments: Characterization of Biopharmaceutical Stability with Differential Scanning Calorimetry

Malvern Instruments: Characterization of Biopharmaceutical Stability with Differential Scanning Calorimetry

Biosimilarity and batch-to-batch comparability.

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Malvern Instruments: Exploring the impact of particle characteristics on suspension rheology

Malvern Instruments: Exploring the impact of particle characteristics on suspension rheology

How particle size, shape and zeta potential influence suspension rheology. Many products are suspensions or dispersions of particles in a liquid medium. Examples range from adhesives, ceramics, paints and inks through to foods, drinks, personal care products and medicines. The physical properties of the dispersed particles in such systems, including particle size, particle size distribution, concentration, electric charge (zeta potential), and even particle shape, can all strongly influence the overall (bulk) rheological properties of a suspension, thereby defining product behavior and functionality. Understanding these interactions is crucial when it comes to achieving desirable product performance, whether it be a stable paint or medicine, workable cement, or a visually appealing shower gel or drink. This white paper examines the impact of particle properties on suspension viscosity, and more broadly on rheological behavior. It looks in some detail at how particle size, shape and zeta potential influence critical aspects of suspension performance such as viscosity and stability and how these properties can be manipulated to tailor this behavior.

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The new MicroCal PEAQ-DSC Automated System

The new MicroCal PEAQ-DSC Automated System

Eight reasons to upgrade from the MicroCal VP-Capillary DSC system. Use of Differential Scanning Calorimetry (DSC) in biopharmaceutical development. Differential scanning calorimetry (DSC) is an established biophysical tool for protein stability characterization during biopharmaceutical drug development. DSC data are used to advance the most stable and 'developable' proteins into the pipeline, and optimize the process and formulation conditions to maintain protein stability during manufacturing and storage.

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Malvern Instruments Discusses GPC/SEC Analysis of Polymer Solutions Used in Inkjet Printing

Malvern Instruments Discusses GPC/SEC Analysis of Polymer Solutions Used in Inkjet Printing

Inkjet printing of polymer solutions is an area of interest for depositing precise, high-throughput patterns of functional polymer. The applications of the polymer patterns include OLEDs, organic circuits, and textiles. The efficacy of this printed pattern can be negatively impacted by the concentration and viscosity of the polymer solution, the molecular weight and molecular weight distribution of the polymer, and level of branching in the polymer. Therefore, it is of keen interest to understand the effect of inkjet printing on the degradation of polymers. In this application note, the molecular weight (MW) and molecular weight distribution (MWD) of various polymers is shown as a function of time during inkjet printing. The data shown in this application note is from references [1-2].

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Malvern Instruments: Gold Nanoparticle Applications and Characterization by Nanoparticle Tracking Analysis

Malvern Instruments: Gold Nanoparticle Applications and Characterization by Nanoparticle Tracking Analysis

This work is a review of nanoparticle size and concentration analysis in gold colloid applications. Gold nanoparticles are one of the most popular and extensively researched type of nanoparticle. A Google Scholar search of the term "gold nanoparticles" results in over 500,000 hits. Applications range from the biological to the material, and include nanomedicine, drug delivery, cancer diagnostics, biological scaffolds, biosensors, contrast agents, catalysts, and CMP slurries for the manufacturing of microprocessor [1].

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Malvern Instruments compares metal powders from different atomization processes using automated image analysis

Malvern Instruments compares metal powders from different atomization processes using automated image analysis

Image analysis is an ideal tool for characterizing the size and shape distributions of atomized metal powders. The manufacture of complex shaped metal parts by Metal Injection Molding (MIM) is a growing industry. The shape and size of metal powders play an important role in determining process efficiency and properties of the final MIM components. Spherical powder particles are typically favored by MIM manufacturers looking to achieve best tolerances and properties in final components. Therefore, it is important to monitor atomized powder to ensure that particles of the desired shape and size are produced.

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Malvern Instruments Explores Nanobubble Applications and Characterization

Malvern Instruments Explores Nanobubble Applications and Characterization

Malvern Instruments conducts an in depth review of ultra-fine bubble (nanobubble) applications and characterization examples. The generation, measurement, and applied technologies of so-called nanobubbles or ultra-fine bubbles, with diameter ranging from tens to hundreds of nanometers, are evolving dramatically in recent years. The unique properties of nanobubbles makes them attractive for a number of applications such as facility cleaning, food disinfection, and water treatment, as well as possibilities in fields such as disinfecting food products, pharmaceutical delivery, decontamination, and manufacturing of functional materials. Preliminary market research conducted by the Fine Bubble Industries Association shows the size of the fine bubble business increasing from USD 20 million in 2010 to USD 4.3 billion in 2020.

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Synergy of Complementary Nanomaterial Characterization Techniques: NTA+DLS

Synergy of Complementary Nanomaterial Characterization Techniques: NTA+DLS

Dynamic Light Scattering (DLS) is a mature and proven technology for nanomaterial characterization. Nanoparticle Tracking Analysis (NTA) is a more recent addition to the spectrum of particle characterization techniques and has many similarities to DLS, leading to some confusion as to their relative capabilities. The broad range of measurement capabilities for each technique is complementary in nature, providing a wealth of valuable information. The differences between the two techniques allow the data from one technology to validate and support the other.

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Using the Zetasizer Nano to Optimize Formulation Stability

Using the Zetasizer Nano to Optimize Formulation Stability

Formulation development is a critical activity for many industries, from pharmaceuticals, to paints and coatings. Indeed, it is estimated that in the UK alone, sales of formulated products amount to some £180 billion per year1. This means that getting formulation ‘right’ is an important goal, with considerable value attached to it. Stability is a crucial attribute for many products with a direct impact on performance, shelf-life, kerb appeal and ultimately, worth. A systematic approach to understanding and developing stability can therefore be extremely helpful in improving the likelihood of success in long-term stability trials and accelerating formulation. The Zetasizer range from Malvern is the world’s most widely used system for nanoparticle, colloid and protein size and zeta potential measurements. In this whitepaper, we examine how these capabilities can be exploited to develop stable dispersions.

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Key Considerations when Purchasing an Advanced GPC/SEC System

Key Considerations when Purchasing an Advanced GPC/SEC System

Investing in a new GPC/SEC system is a big decision with many factors to consider. This white paper lists the key items that you should think about when buying a new system and discusses the reasons for their importance. Finally, it discusses what Malvern has to offer in this area.

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Going with the Flow: Malvern Instruments’ Basic Introduction to Rheology

Going with the Flow: Malvern Instruments’ Basic Introduction to Rheology

Rheology concerns itself with materials that have aspects of both solids and liquids, and researches the flow and deformation of matter. Malvern Instruments explores this study, and reveals its fundamental in relation to force, deformation and time.

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Malvern Instruments Shares its Buyer’s Guide to Protein Stability Measurement Platforms

Malvern Instruments Shares its Buyer’s Guide to Protein Stability Measurement Platforms

As a leader in best practices during biopharmaceutical development, Malvern Instruments sheds light on effective protein stability analysis technologies for the biopharmaceutical industry.

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Five Ways That the Mastersizer 3000 Saves you Money

Five Ways That the Mastersizer 3000 Saves you Money

To earn its place in today’s busy analytical laboratories, an instrument must meet certain practical criteria, and stand-up to rigorous economic evaluation. For labs that need particle sizing, laser diffraction systems are typically the technology of choice; delivering accurate and reliable information for the broadest range of sample types. Here, we look at how the Mastersizer 3000, the market leading laboratory particle size analyzer from Malvern Instruments, can save you time, money and resources, and ultimately deliver a healthy return on investment.

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Time to Spec up? Top Five Reasons to Replace a Viscometer with a Rheomete

Time to Spec up? Top Five Reasons to Replace a Viscometer with a Rheomete

Is your viscometer approaching the end of its life? Are you starting to feel that your trial and error, ‘rheology-light’ approach to formulation is becoming dated? Or are there longstanding product performance issues that you’re failing to gain traction with, where you suspect rheology may hold the answer?

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Biophysical Characterization of Epigenetic Protein Interactions

Biophysical Characterization of Epigenetic Protein Interactions

Epigenetics is the study of heritable changes in gene expression caused by nongenetic mechanisms, without alterations in gene structure or DNA sequence. The epigenetic state of a cell evolves during the cellular differentiation and development of an organism, and epigenetic changes are linked to cellular reprogramming. Because epigenetic mechanisms may also be responsible for the integration of environmental responses at he cellular level, they potentially play an important role in the development of som diseases.

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Overcoming and Quantifying ‘Wall Slip’ in Measurements from a Rotational Rheometer

Overcoming and Quantifying ‘Wall Slip’ in Measurements from a Rotational Rheometer

When making shear rheological measurements on structured liquids, in particular suspensions, emulsions or foams there is a high probability that the measurement may be affected by a phenomenon known as 'wall slip'. Wall slip generally results from a localdepletion of the dispersed phase near the geometry walls, effectively forming a lubrication layer at the surface. As a consequence bulk rheological properties are no longer being accurately measured leading to an underestimation of the true viscosity. A similar effect can be observed when measuring solid like materials where there is insufficient friction between the sample and the wall to support the applied stress.

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Preformulation and Stability Studies of Biotherapeutics Using DSC

Preformulation and Stability Studies of Biotherapeutics Using DSC

The use of biotherapeutics, such as antibodies and other protein molecules, to treat diseases is a rapidly growing field in the pharmaceutical industry.Biotherapeutics are often required at high concentrations and multiple doses, hence a manufacturer must produce kilogram quantities or more of the protein drug. The manufacturing process for biotherapeutics involves protein expression in thousands of liters of bioreactor medium followed by a purification process using large-scale chromatography columns and filtration systems.

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Protein Storage and Stability Analysis Using the Zetasizer Nano ZSP

Protein Storage and Stability Analysis Using the Zetasizer Nano ZSP

Spidroins are a unique family of large, structural proteins that make up the bulk of spider silk fibres. The mechanical strength and elasticity of spider silk fibres have led to their successful use in the regeneration of peripheral nerves in rats [1], with the same properties giving the potential for use in a wide range of other applications [2,3,4]. The production of these proteins on an industrial scale, however, has only become possible fairly recently

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Using Differential Scanning Calorimetry to Inform and Accelerate Process Development for Protein Therapeutics

Using Differential Scanning Calorimetry to Inform and Accelerate Process Development for Protein Therapeutics

The production and purification of immunoglobulins of the gamma isotype, particularly human IgG1, for diagnostic or therapeutic applications is now fairly routine. In the past decade IgE-based therapeutics have also gained momentum (1-3). IgE is important for host defense against parasites and for protective inflammation. Yet, IgE-mediated signaling through its receptors is also a focal point of inflammatory allergic disease (4). The constant region of IgE, is a homodimer containing duplicate pairs of three unique Ig-fold domains (Cε2, Cε3, and Cε4), and is responsible for binding its two receptors, FcεRI and CD23, also known as FcεRII.

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Evaluating Product Texture Using Oscillatory Testing on a Rotational Rheometer

Evaluating Product Texture Using Oscillatory Testing on a Rotational Rheometer

Formulating products to have both the correct functional and sensory attributes can be a difficult task. The latter in particular relies heavily on user feedback which can take considerable time and effort to attain. In addition it is not always easy to interpret such feedback in the context of material properties and hence rheological data.

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NTA: Drug Nanocarriers

NTA: Drug Nanocarriers

Part 6 of NTA 1000 publications review.

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NTA: Applications in Drug Delivery

NTA: Applications in Drug Delivery

Part 5 of NTA 1000 publications review.

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Estimating BSA Aggregation Kinetics with Dynamic Light Scattering and Raman Spectroscopy

Estimating BSA Aggregation Kinetics with Dynamic Light Scattering and Raman Spectroscopy

Towards a unified biophysical characterization platform: Combining dynamic light scattering and Raman spectroscopy*.

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An Introduction to DLS Microrheology

An Introduction to DLS Microrheology

Microrheology techniques involve tracking the motion of dispersed probe (or tracer) particles in a complex fluid, to extract local and bulk rheological properties of the matrix. Analogous to mechanical rheometry techniques, a stress is applied to the system by motion of the probe particle, and the deformation (or strain) is measured through changes in the probe particle position.

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A Basic Guide to Particle Characterization

A Basic Guide to Particle Characterization

The aim of this guide is to provide a basic grounding in the main particle characterization techniques currently in use within industry and academia.

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NTA: Environmental Impact of Nanoparticles

NTA: Environmental Impact of Nanoparticles

Part 4 of NTA 1000 publications review.

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NTA: Nanoparticle Toxicity

NTA: Nanoparticle Toxicity

At the same time as an increasing interest in, and rapid development of, a wide range of materials and products containing nanoscale structures and engineered nanoparticles, awareness has grown that the longer term potential toxic effects of such materials and their potential environmental impact are poorly understood. Existing methods have been assessed and new methods sought by which such materials could be analyzed on a routine basis during development and manufacture.

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Orthogonal and Complementary Nanoparticle Characterization Techniques

Orthogonal and Complementary Nanoparticle Characterization Techniques

How can I trust my data? This is a common concern for many researchers using particle measurement instrumentation. Is the data affected in any way by the measurement technology, or alternatively by the user during sample preparation or by the analysis parameters employed? To answer this question we need to consider the use of independent and orthogonal measurement techniques in order to provide confidence and measurement validation.

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The Benefits of Real-Time Analysis for Process Development

The Benefits of Real-Time Analysis for Process Development

While much effort is expended in optimizing commercially operating plant, getting the process 'right first time' can be far more efficient. Real-time analysis of process parameters provides substantial support during development, streamlining and accelerating the evolution of successful process designs. Taking on-line particle size analysis as an example, this paper considers the rationale for investing in real-time measurement for pilot scale work. Case studies illustrate the various ways in which on-line systems promote efficient process development, easing the transition into profitable manufacture.

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Towards a Unified Biophysical Characterization Platform: Combining Dynamic Light Scattering and Raman Spectroscopy to Determine Protein Structure and Stability

Towards a Unified Biophysical Characterization Platform: Combining Dynamic Light Scattering and Raman Spectroscopy to Determine Protein Structure and Stability

The combination of dynamic light scattering (DLS) with Raman spectroscopy has the capability to characterize a wealth of chemical, structural, and physical parameters of therapeutic proteins. Raman spectroscopy simultaneously derives protein secondary structure markers (amide I and III) and tertiary structure markers (aromatic side chains, disulfide bond, hydrogen bonding, local hydrophobicity). These markers can be monitored under controlled conditions by the determination of spectral peak position, shape, and/or intensity. Raman is able to make these structural determinations at formulation concentrations, 50 mg/mL or greater, rather than at the diluted concentrations required by conventional methods, i.e. typically less than a few mg/mL for circular dichroism (CD).

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Top Ten Things to Consider When Migrating to the Mastersizer 3000 from the Mastersizer 2000

Top Ten Things to Consider When Migrating to the Mastersizer 3000 from the Mastersizer 2000

Previously, we've published 11 things to consider when purchasing a laser diffraction system. With the launch of the Mastersizer 3000, how can you choose between the Mastersizer 3000 and the popular Mastersizer 2000 that has sold more than 11,000 units worldwide? This white paper outlines the new capabilities of the Mastersizer 3000 and highlights the support Malvern provides to help you transfer methods from the Mastersizer 2000 to the new system.

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Nanoscale Material Characterization: a Review of the use of Nanoparticle Tracking Analysis (NTA)

Nanoscale Material Characterization: a Review of the use of Nanoparticle Tracking Analysis (NTA)

This white paper describes the central role of high resolution particle size and concentration measurement nanoparticle research. The technique of Nanoparticle Tracking Analysis (NTA) is described and compared to other characterization methodologies, and comparative papers are cited. A wide range of application studies is then summarized with specific reference to the use and value of NTA.

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Characterization of Single Wall Carbon Nanotubes (SWNTs) by combining Dynamic Light Scattering and Raman Spectroscopy

Characterization of Single Wall Carbon Nanotubes (SWNTs) by combining Dynamic Light Scattering and Raman Spectroscopy

The combination of DLS and Raman spectroscopy offers the ability to measure the length, diameter, and chirality of carbon nanotubes in a single experiment. These parameters can be used with existing empirical knowledge of nanotubes to predict their conductivity and strength characteristics.

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Measuring the Rheology of Polymer Solutions

Measuring the Rheology of Polymer Solutions

Polymers are versatile materials that play an important role in a diverse range of industrial applications. Polymeric solutions or suspensions provide joint lubrication in the human body, make foods appear rich and creamy, and impart stability to inks and paints. In these and many other applications the rheological characteristics of the polymer solution have a defining influence on product performance and functionality.

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Isothermal Titration Calorimetry: Theory and Practice

Isothermal Titration Calorimetry: Theory and Practice

Isothermal titration calorimetry (ITC) is an analytical technique that has become the "gold standard" for studying intermolecular interactions. As its name indicates, it is a titrimetric technique, that is, a volumetric laboratory method for quantitative chemical analysis (traditionally intended to determine the unknown concentration of an identified analyte) where a reagent solution, the titrant, is made to react with a solution of analyte or titrand.

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What are the Benefits of Owning a Malvern Particle Size Analyzer?

What are the Benefits of Owning a Malvern Particle Size Analyzer?

A recent Malvern customer survey allowed us to ask our customers about the Malvern laser diffraction particle sizing equipment they owned (Mastersizer and Spraytec), how they used it and what they liked most about it.

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12 Key Considerations When Purchasing a Rheometer

12 Key Considerations When Purchasing a Rheometer

This whitepaper outlines the 12 key considerations when purchasing a Rheometer.

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Ten Reasons Polymer Characterization Scientists Should Upgrade From Single to Multi-Detector GPC

Ten Reasons Polymer Characterization Scientists Should Upgrade From Single to Multi-Detector GPC

This white paper lists the top ten reasons to consider an advanced multi-detector GPC system.

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Characterizing Polymers: Techniques for the Measurement of Molecular Weight, Molecular Size and Branching

Characterizing Polymers: Techniques for the Measurement of Molecular Weight, Molecular Size and Branching

This whitepaper reviews the methods available for measuring the key characteristics of polymers focusing on the benefits and value of gel permeation / size exclusion chromatography (GPC/SEC). Much of the paper talks exclusively about polymers, however many of the principles discussed are equally applicable to proteins or protein conjugate materials.

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Analytical Strategies for Ink Formulation

Analytical Strategies for Ink Formulation

Controlling the performance of an ink is a complex optimization challenge. Understanding how features of the system, the dispersed particle size in particular, impact stability and behavior during each stage of the printing process is crucial for effective formulation. This white paper offers practical guidance on using a range of analytical techniques, including rheology, and particle size and zeta potential measurement to generate the required knowledge.

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Carbon and Carbon Nanotube Characterization by Nanoparticle Tracking Analysis

Carbon and Carbon Nanotube Characterization by Nanoparticle Tracking Analysis

This white paper discusses examples where Nanoparticle Tracking Analysis is helping to understand these carbon-based nanostructures.

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Viruses and Viral Vaccines: Characterization by Nanoparticle Tracking Analysis

Viruses and Viral Vaccines: Characterization by Nanoparticle Tracking Analysis

NTA utilizes the properties of both light scattering and Brownian motion in order to obtain the particle size distribution of samples in liquid suspension. A laser beam is passed through the sample chamber, and the particles in suspension in the path of this beam scatter light in such a manner that they can easily be visualized via a 20x magnification microscope onto which is mounted a camera.

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Understanding Taylor Dispersion Analysis

Understanding Taylor Dispersion Analysis

Taylor Dispersion Analysis (TDA) is a microcapillary flow-based technique whereby a nanoliter-scale sample pulse is injected into the laminar flow of run buffer, which then spreads out axially due to the combined actions of convection and radial diffusion. Detection of the equilibrium concentration profile (or Taylorgram) of the dispersed sample pulse allows the molecular diffusion coefficient and hence hydrodynamic radius of solute molecules to be calculated.

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Extending the Boundaries of QbD

Extending the Boundaries of QbD

The last decade has seen a shift within the pharmaceutical industry towards a design space approach to development and manufacture, an agenda underpinned by ICHQ8, Q9 and Q10 and the concept of Quality by Design (QbD). However, because a design space approach naturally focuses attention on the areas of a project that are potentially the most vulnerable to failure it has broader value for risk management.

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Measuring Environmental Impact of Nanomaterial Wastes and Contaminants Using Nanoparticle Tracking Analysis

Measuring Environmental Impact of Nanomaterial Wastes and Contaminants Using Nanoparticle Tracking Analysis

The increasing number of nanomaterial based consumer products raises concerns about their possible impact on the environment. Suitable methods for their analysis are a particular problem in this regard. This white paper reviews the use of Nanoparticle Tracking Analysis (NTA) in addressing this need.

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Assessing Nanoparticle Toxicity in Waste Water using Nanoparticle Tracking Analysis

Assessing Nanoparticle Toxicity in Waste Water using Nanoparticle Tracking Analysis

At the same time as an increasing interest in, and rapid development of, a wide range of materials and products containing nanoscale structures and engineered nanoparticles, awareness has grown that the longer term potential toxic effects of such materials and their potential environmental impact are poorly understood. Existing methods have been assessed and new methods sought by which such materials could be analyzed on a routine basis during development and manufacture.

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Addressing the Needs of Drug Discovery with the MicroCal PEAQ-ITC Instruments

Addressing the Needs of Drug Discovery with the MicroCal PEAQ-ITC Instruments

This white paper highlights the advantages of the new ITC instruments—MicroCal PEAQ-ITC and MicroCal PEAQ-ITC Automated systems and MicroCal PEAQ-ITC Analysis Software. The software allows analysis of binding interactions complicated by the presence of inactive protein material, incorrect protein concentration, and/or inaccurate concentration or heterogeneity of compound solutions.

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Use of the new MicroCal PEAQ-ITC System for Measurement and Characterization of a Broad Range of Protein-LMW Compound Interactions

Use of the new MicroCal PEAQ-ITC System for Measurement and Characterization of a Broad Range of Protein-LMW Compound Interactions

This white paper highlights the beneficial features of the new MicroCal PEAQ-ITC instrument and software for the analysis of binding interactions through direct and competitive titrations.

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Microcal ITC Systems

Microcal ITC Systems

Understanding biomolecular interactions.

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Important Factors when Buying a Differential Scanning Calorimeter (DSC)

Important Factors when Buying a Differential Scanning Calorimeter (DSC)

The physical components and features of a Differential Scanning Calorimeter (DSC) instrument and the technical specifications are clearly important to consider when purchasing a new system. However, written specifications can be confusing, misleading and may actually have very little bearing on the actual performance of the instrument. Specifications, on paper, do not necessarily translate into advantages or disadvantages when it comes to making measurements on your samples.

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Understanding the Effect of Molecular Weight and Structure on the Performance Characteristics of Cellulose Derivatives using OMNISEC

Understanding the Effect of Molecular Weight and Structure on the Performance Characteristics of Cellulose Derivatives using OMNISEC

A key family of molecules of interest to the pharmaceutical industry is those derived from cellulose such as hydroxyethyl cellulose and others. These macromolecules are typically used as viscosity modifiers for various products such as eye drops and moisturizing creams, and as excipients in many other applications.

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Forensic Analysis of an Artificial Sweetener Commonly Employed in Hoax Powder Attacks Using Morphologically Directed Raman Spectroscopy

Forensic Analysis of an Artificial Sweetener Commonly Employed in Hoax Powder Attacks Using Morphologically Directed Raman Spectroscopy

In the wake of the September 11th terrorist attacks, there was an influx of white powder events throughout the United States. A white powder event is when an unknown white powder is received in the post. More often than not, the attacks do not contain any toxic materials and are carried out for the sole purpose of causing terror and damaging infrastructure. Since these attacks, the FBI and US Postal Service have responded to thousands of white powder events.

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Characterisation of IgG Monomers and their Aggregates

Characterisation of IgG Monomers and their Aggregates

Whether we are trying to improve candidate formulations or trying to characterize final formulations, knowing exactly what a protein sample comprises and how much we have of each component is of paramount importance.

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Evaluating the Rheological Properties of Hyaluronic Acid Hydrogels for Dermal Filler Applications

Evaluating the Rheological Properties of Hyaluronic Acid Hydrogels for Dermal Filler Applications

Hyaluronic acid (HA) is a naturally occurring polysaccharide frequently used as a functional ingredient in many topical and subcutaneous anti-ageing treatments such as dermal fillers, which exploit the polymer’s unique viscoelastic properties for effective soft tissue augmentation. When administered subcutaneously, HA builds an elastic network within wrinkles and rhytides to give the skin a plumper and fuller look.

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Characterisation of Pollen Samples with the Morphologi® G3SE

Characterisation of Pollen Samples with the Morphologi® G3SE

Some of the most frequent inhalant allergens from the natural environment are present in pollen grains and a wide range of pollen source material is used in the production of immunotherapy or diagnostic products as well as in allergy research.

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New Parsum Probe IPP 80-P

New Parsum Probe IPP 80-P

Parsum presented a new probe type on the Powtech (30. Sep – 02 Oct 2014) in Nuremberg. The IPP 80-P is especially made for application in pharma industry. Design is completely in stainless steel and it will be available only as an ATEX certified type. The USB-box will be integrated into the barrier housing, so cabling and installation will become simpler.

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Flyer Parsum 2014

Flyer Parsum 2014

Valuable Insight in your Process.

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An Introduction to OMNISEC REVEAL

An Introduction to OMNISEC REVEAL

This technical note describes the system and explains how OMNISEC sets a new standard in molecular characterization.

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An Introduction to OMNISEC RESOLVE

An Introduction to OMNISEC RESOLVE

This technical note describes the features and benefits of OMNISEC RESOLVE. It also includes a discussion of the value of OMNISEC as a complete system as opposed to upgrading an existing conventional system to advanced detection.

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The Mark–Houwink plot – Differentiation of Branching and Composition

The Mark–Houwink plot – Differentiation of Branching and Composition

In this application note, we will show how to separate the effects of a structural difference induced by a compositional change to a polymer (e.g. substitution) and the structural change induced by polymer chain branching.

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GPC/SEC Analysis of Polylactic Acid (PLA) and Poly(lactic-co-glycolic acid) (PLGA) Using OMNISEC

GPC/SEC Analysis of Polylactic Acid (PLA) and Poly(lactic-co-glycolic acid) (PLGA) Using OMNISEC

In this application note, a selection of different PLA and PLGA polymer samples were analyzed on Malvern's OMNISEC GPC/SEC system, which combines all the detectors described above.

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GPC Characterisation of Nylon using Formic Acid for Reduced Cost per Analysis

GPC Characterisation of Nylon using Formic Acid for Reduced Cost per Analysis

Gel permeation chromatography (GPC) or, equivalently, size-exclusion chromatography (SEC) is a widely used technique to characterise a wide variety of macromolecules, including, but not limited to commodity or bulk manufactured polymers. This technique can be used to measure the molecular weight moments, molecular weight distribution, the intrinsic viscosity, and/or hydrodynamic size of these macromolecules. While conditions that are both effective and practical have been determined for many of these commodity polymers (i.e. THF for polystyrene, chlorinated benzenes for polyolefins), some need further optimization in one aspect or another. This application note describes one such polymer, nylon, where changes in operating conditions can lead to improvements in both cost and health and safety.

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Application of Dynamic Light Scattering (DLS) to Protein Therapeutic Formulations: Principles, Measurements and Analysis – 2. Concentration Effects and Particle Interactions

Application of Dynamic Light Scattering (DLS) to Protein Therapeutic Formulations: Principles, Measurements and Analysis – 2. Concentration Effects and Particle Interactions

In this four-part white paper series, common issues and questions surrounding the principles, measurements and analysis of DLS data are discussed in order to help minimize the time required for and complexity of acquiring and interpreting DLS data that is critical throughout the development process. In this second white paper of the series, we cover the influence of concentration effects and particle interactions on DLS results and provide a roadmap for identifying and distinguishing each type of concentration effect.

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Ten Reasons That the Zetasizer Nano is Chosen for Scientific Success

Ten Reasons That the Zetasizer Nano is Chosen for Scientific Success

New components and measurement techniques continue to be introduced for the Zetasizer Nano. New to the system are a Surface Zeta Potential accessory and a new diffusion barrier method for improved zeta potential measurements of protein samples. Why is the Malvern Zetasizer Nano so popular and found in a broad range of applied and fundamental scientific projects across all industries and fields? Because, it is simply the most dynamic and broad ranged instrument on the market for solving technical issues in today's research environment and it continues to evolve with new capabilities. Here are ten reasons why you should choose the Zetasizer Nano:

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Exosomes and Microvesicles: Characterisation by Nanoparticle Tracking Analysis

Exosomes and Microvesicles: Characterisation by Nanoparticle Tracking Analysis

While the principles underpinning the Nanoparticle Tracking Analysis (NTA) technique have been described in an earlier white paper, it must be reiterated that the use of high intensity laser beams combined with a low-background optical configuration allows particles of deeply sub-micron dimensions to be visualised, the lower range of particle sizes measureable depending on particle refractive index.

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Viruses and Viral Vaccines: Characterisation by Nanoparticle Tracking Analysis

Viruses and Viral Vaccines: Characterisation by Nanoparticle Tracking Analysis

NTA utilises the properties of both light scattering and Brownian motion in order to obtain the particle size distribution of samples in liquid suspension. A laser beam is passed through the sample chamber, and the particles in suspension in the path of this beam scatter light in such a manner that they can easily be visualised via a 20x magnification microscope onto which is mounted a camera. The camera, which operates at approximately 30 frames per second (fps), captures a video file of the particles moving under Brownian motion within the field of view of approximately 100μm x 80 μm x 10 μm (Figure 1).

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How can Nanoparticle Tracking Analysis Assist in the Production of Nanoparticles

How can Nanoparticle Tracking Analysis Assist in the Production of Nanoparticles

This white paper highlights the growth in the use of the technique of Nanoparticle Tracking Analysis as applied to nanoparticles and nanomaterials production and analysis, from the very first reports on nanoscale silver and gold (Lundahl et al. (2008) and Marsh et al. (2008), respectively).

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Studying Low-Affinity Fragments of Ligands by ITC

Studying Low-Affinity Fragments of Ligands by ITC

Molecular recognition is a fundamental prerequisite to all biological processes from enzymatic catalysis to signal transduction. The modern pharmaceutical industry is built upon the concept of selective intervention in such systems (1). Furthermore, similar concepts are being implemented, through supramolecular chemistry, to develop novel smart materials, components for nanotechnology and molecular electronics (2). If we are to harness the full potential of molecular recognition, it is essential that we understand the subtle interplay between structure and thermodynamics in complex formation.

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Pharmaceutical Excipient Characterisation

Pharmaceutical Excipient Characterisation

The aim of formulation development is to design a product and its manufacturing process to consistently deliver the intended Quality Target Product Profile (QTPP). This involves determining the Critical Quality Attributes (CQAs) for the Active Pharmaceutical Ingredient (API) and excipients that define the performance of the product. These are generally identified through an assessment of the extent to which the variation in a specific attribute, for example particle size, can impact the drug product’s quality and performance.

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Differentiation and Characterisation of Subvisible Particulates in Therapeutic Protein Products

Differentiation and Characterisation of Subvisible Particulates in Therapeutic Protein Products

The formation of protein aggregates is a particular concern for parenteral administration biopharmaceuticals due to the potential for increased immunogenicity. As a consequence, there is an expectation from regulatory agencies for companies to monitor and, if required, reduce the levels of sub-visible particles present in therapeutic protein from manufacture through their complete shelf life.

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Revealing Kinase Inhibitor Mechanisms: ITC Leads the Way

Revealing Kinase Inhibitor Mechanisms: ITC Leads the Way

The kinome of an organism is the set of protein kinases in its genome and these protein-modifying enzymes are potential targets in a number of therapeutic areas. Studies to characterise the human kinome, together with the explosion of available kinase crystal structures over recent years, have led to an increased focus on kinases as potential targets for pharmaceutical intervention.

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Ten Ways to…Optimise Rheology to Increase Dispersion/Colloidal/Emulsion Stability

Ten Ways to…Optimise Rheology to Increase Dispersion/Colloidal/Emulsion Stability

The following ten points highlight general methods of designing and interpreting rheological tests to optimise sample stability.

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Identification of Agglomerates Using Automated Image Analysis

Identification of Agglomerates Using Automated Image Analysis

The identification of agglomerates is seen as a challenge across many different industries. Automated image analysis systems provide a means for the classification of agglomerates, by differentiating particles based on their morphological parameters. The inclusion of spectroscopic measurements alongside imaging (MDRS) aids in understanding the type of agglomeration occurring with the sample.

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Ensuring Accurate and Repeatable Measurement of Proteins Using the Zetasizer APS

Ensuring Accurate and Repeatable Measurement of Proteins Using the Zetasizer APS

In this application note, well known protein samples were used in a crosscontamination test to investigate the accuracy and repeatability of the Zetasizer APS dynamic light scattering (DLS) system.

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Effect of Excipients on Protein Formulation Viscosity

Effect of Excipients on Protein Formulation Viscosity

In the development of injectable biotherapeutics, drug efficacy and patient experience are both very important parameters. In order to maximize activity and efficacy, biotherapeutics are usually delivered intravenously or subcutaneously in high concentrations, typically >100g/mL, due to their short half-life in plasma.

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Reverse Engineering of a Pharmaceutical Formulation Using the Morphologi G3-ID

Reverse Engineering of a Pharmaceutical Formulation Using the Morphologi G3-ID

According to the definition established by the FDA, a generic drug is "a drug product which is comparable to a reference listed drug (RLD) product in dosage form, strength, route of administration, quality, performance characteristics, and intended use". Rigorous rules and regulations pertaining to abbreviated new drug application (ANDA) submissions are complex and the generic drug industry strives to meet these regulations to obtain FDA's approval.

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Molecular Weight Measurements of an Antibody Using Viscotek SEC-MALS 20

Molecular Weight Measurements of an Antibody Using Viscotek SEC-MALS 20

Therapeutic recombinant antibodies, primarily of the Immunoglobulin G isotype (IgG), represent a growing proportion of biopharmaceuticals. There are an ever increasing number of approved antibody therapies available to treat a variety of modern-day diseases such as cancer, rheumatoid arthritis and diabetes. With many more candidate IgG's in the biopharmaceutical development pipeline the pressure to accurately understand and develop these candidates becomes more and more important.

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The use of ITC for Obtaining Enzyme Kinetic Constants

The use of ITC for Obtaining Enzyme Kinetic Constants

Enzymes are proteins that function as biological catalysts and they play a crucial role in nearly all processes that take place in living organisms. Therefore studies of these molecules and the reactions they catalyze have been a core activity for biochemists for at least the past fifty years.

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Understanding the Conformational Stability of Protein Therapeutics using Raman Spectroscopy

Understanding the Conformational Stability of Protein Therapeutics using Raman Spectroscopy

The combination of Dynamic Light Scattering (DLS) with Raman Spectroscopy provides the ability to extract a wealth of chemical, structural, and physical information about biotherapeutic proteins under formulation conditions.

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Using Laser Diffraction Particle Size Data to Optimise the Performance of Sprays

Using Laser Diffraction Particle Size Data to Optimise the Performance of Sprays

Many industries share the need to closely control the characteristics of sprays, albeit for very different reasons, and one of the most critical parameters is the particle size of the droplets within the spray plume.

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Developing a Bioformulation Stability Profile

Developing a Bioformulation Stability Profile

When used in combination, light scattering and microcapillary viscometry can be used to develop a stability profile to screen biotherapeutic candidates, with light scattering providing a suite of dilute solution properties and microcapillary viscometry providing analysis of viscosity even at high sample concentration.

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Real-Time Particle Sizing for Granulation Control

Real-Time Particle Sizing for Granulation Control

This paper considers various granulation processes and the use of real-time particle size measurement in their optimisation, focusing on two different sizing methods: laser diffraction and the spatial filter technique (SFT).

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Laser Diffraction and Automated Imaging: Complementary Techniques for Nasal Spray Development

Laser Diffraction and Automated Imaging: Complementary Techniques for Nasal Spray Development

Nasal spray products are increasingly valued for delivering systemic as well as locallyacting therapies, most notably hormone and migraine treatments. The large surface area and rich blood supply of the nasal passages aid the rapid absorption of drug entities, with their close proximity to the central nervous system being of particular benefit.

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Automation of QC Microscope Measurements of a Pharmaceutical Ointment Using the Morphologi Particle Characterisation System

Automation of QC Microscope Measurements of a Pharmaceutical Ointment Using the Morphologi Particle Characterisation System

In Quality Control (QC) procedures many pharmaceutical companies rely on microscope-based analyses to identify, qualify and or quantify solid particles meeting specified size criteria.

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Applications of Isothermal Titration Calorimetry and Differential Scanning Calorimetry in Biopharmaceutical

Applications of Isothermal Titration Calorimetry and Differential Scanning Calorimetry in Biopharmaceutical

Development of protein-based therapeutics is a challenging task due to inherent protein instabilities, which can manifest as physical instability (unfolding, aggregation, adsorption), and chemical degradation (oxidation, deamidation, cleavage). Such instabilities can lead to reduced activity of the protein or even generation of potentially immunogenic species.

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Evaluating Product Delivery Characteristics from a Bottle, Tube or Spray Pack

Evaluating Product Delivery Characteristics from a Bottle, Tube or Spray Pack

Many consumer products are packaged in tubes or bottles where product application involves pumping the product through a nozzle. Such products tend to be shearthinning products where the viscosity drops during the extrusion process due to the increasing shear rate, and then recovers on exiting the nozzle as the shear rate is reduced.

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Differential Scanning Calorimetry as a Tool for Rapid and Efficient Development of Economical Biopharmaceutical Processes

Differential Scanning Calorimetry as a Tool for Rapid and Efficient Development of Economical Biopharmaceutical Processes

Biopharmaceutical process development can be costly and time-consuming. The ultimate goal is to maximise the yield of purified product by the most costeffective, reproducible and robust route.

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Using Differential Scanning Calorimetry to Accelerate Liquid Formulation Development for Protein Biopharmaceuticals

Using Differential Scanning Calorimetry to Accelerate Liquid Formulation Development for Protein Biopharmaceuticals

Monoclonal antibody development projects exist for a wide variety clinical indications. Recombinant proteins of commercial interest, including monoclonal antibodies, need additional properties beyond their biological activity to enable their development into successful biopharmaceuticals.

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Enhanced Aggregate Detection: Monitoring

Enhanced Aggregate Detection: Monitoring

The high sensitivity of dynamic light scattering (DLS) to protein aggregation explains the wide use of Zetasizer instruments within the biopharmaceutical industry. Since the amount of light scattered by a particle is proportional to size, trace amounts of aggregate can be detected and sized using DLS.

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Drug Development: Accelerating Time to Market

Drug Development: Accelerating Time to Market

Discovering and developing drugs is becoming a progressively expensive, high-risk venture and pharmaceutical development has less resource from which increased productivity is expected.

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Quick Contact Malvern Panalytical

Malvern Panalytical to Host Ore and Minerals Analysis (OMA) Worldwide Workshops

Throughout the year Malvern Panalytical organizes multiple OMA workshops all over the world. During these free-of-charge seminars, dedicated to the...
29th October 2019

Global Standards Developer ASTM International Schedules Board Meeting and Events

ASTM International, one of the world’s leading standards developers, will be holding its board meeting and related events in Boston,...
4th October 2019

Collaboration between University of Bristol and Malvern Panalytical to Boost Data Science and Digital Technologies Expertise

Bringing academia and business together to solve global challenges.
24th September 2019

Manufacturers Choose the Mastersizer 3000 for Accurate and Efficient Particle Size Analysis

Justin Hoover, Quality Manager at Metals and Additives LLC, discusses the company’s requirement for an instrument that was more efficient,...
3rd September 2019

Examine Reaction Kinetics of Mortar about 100 Times Faster with HiPer Small Spot Mapping

Malvern Panalyticals latest HiPer Small Spot Mapping (HiPer SSM) addition on the Zetium platform offers user-independent results that are accurate...
3rd September 2019

Dolomite Microfluidics Simplifies Nanomaterial Development Workflow with Malvern Panalytical’s Zetasizer Ultra

The Dolomite Microfluidics team found the Zetasizer Ultra trivial to set up in their lab and found that most of...
27th August 2019

Renowned Researchers Leverage Malvern Panalytical’s ASD TerraSpec® Halo Mineral Identifier to Advance Investigation of Life on Mars

Malvern Panalytical instrument used for testing planetary field geology and mineralogy at terrestrial analogue sites in Arizona and Utah.
17th July 2019

Industry Leaders Come on Board as NMiTE Adds Engineering Expertise

The New Model in Technology and Engineering (NMiTE) has announced three appointments to its Board of Trustees.
2nd July 2019

Webinar: Particle Size Masterclass – Method Development

Malvern Panalytical has announced its new webinar, 'Particle size Masterclass - Method Development'.
23rd April 2019

Webinar – Zetasizer Pro and Ultra: An Evolution in Light Scattering Technology

Join Malvern Panalytical at its webinar 'The New Zetasizer Pro and Ultra: An Evolution in Light Scattering Technology'.
18th April 2019

Elemental Determination of Ferrochromium Alloys by Borate Fusion for XRF Analysis

Malvern Panalytical has announced its new webinar: 'Elemental determination of Ferrochromium Alloys by Borate Fusion for XRF Analysis'.
16th April 2019

Webinar: Get the Most Out of Your HighScore(Plus)

Malvern Panalytical has announced its new PR, 'Get the Most Out of Your HighScore(Plus) with the Latest Functionalities and Improvements'.
11th April 2019

Webinar: Field Spectroscopy with the ASD FieldSpec® Dual Collection Software

Malvern Panalytical will be hosting its latest webinar 'Learn From the Experts - Field Spectroscopy with the ASD FieldSpec® Dual...
10th April 2019

Webinar: Laser Diffraction Masterclass

Malvern Panalytical is proud to announce its latest webinar: 'Laser Diffraction Masterclass 1 – Back to Basics'.
9th April 2019

Webinar: Development Efficiency of Drug-Encapsulating Nanoparticles

Malvern Panalytical has announced its new webinar: 'Improving the Development Efficiency of Drug-Encapsulating Nanoparticles Using Microfluidics and Multi-Angle Dynamic Light...
4th April 2019

Malvern Panalytical’s Seminars in April and May

Malvern Panalytical has announced that it will be hosting some seminars in April, including a GSK Singapore User Day Workshop...
29th March 2019

EPSILON 1: The Next Generation

The next generation of Epsilon 1 X-ray fluorescence (XRF) spectrometers has been launched today by Malvern Panalytical.
18th March 2019

Webinar: How Analysis by Spectroscopy Optimises Agriculture of Grasslands

This webinar discusses how remote sensing and visual near-infrared spectroscopy is used to create a process of analysis that optimises agriculture...
13th February 2019

Webinar: Is my Particle Sizing System Fit For Purpose?

Deploying an analytical instrument within a laboratory can be expensive, both in terms of the cost of the system itself...
7th February 2019

Webinar: If Particles be the Food of Love

In this Valentine’s Day themed webinar, Malvern Panalytical will share the partnership of image analysis and laser diffraction through the...
5th February 2019

Webinar: Building Integrity into Your Analytical Workflow

Integrity in the analytical workflow for pharmaceutical development relies on understanding how both your processes and also the physical characteristics...
24th January 2019

Webinar: Automated Powder Recycling and QA for Additive Manufacturing

Metal additive manufacturing (AM) is often billed as the future of manufacturing, providing unlimited possibilities in terms of part design...
22nd January 2019

Webinar: When is a particle not a particle?

The interpretation of particle size data gathered by dynamic light scattering (DLS) can be fraught with confusion, especially when results...
15th January 2019

2019 Colorado Protein Stability Conference

Protein stability is important in numerous disciplines, ranging from basic and medical biochemistry to pharmaceutical sciences.
11th January 2019

Webinar: Basic Principles of Particle Characterisation

Malvern Panalytical has announced its latest webinar, Basic Principles of Particle Characterisation by Automated Image Analysis.
11th January 2019

Albemarle’s Ribbon-Cutting Ceremony

A ribbon-cutting ceremony marking the successful installation of the Claisse® rFusion system for Albemarle Corporation was held on 2 May...
3rd January 2019

Webinar: Advanced Software Suite for Analysis of Layered Structures

Malvern Panalytical's new Advanced Material Analysis and Simulation Software (AMASS) suite offers a wealth of key information to characterise your layered structures. Join this...
1st January 2019

Webinar: Optimising Metal Powder Properties for Manufacturing Processes

Characterising the physical and structural properties of metal powders for use in near net shape manufacturing processes is important for...
6th December 2018

Seminar: Malvern Panalytical Live

Malvern Panalytical has announced a one-day, free-to-attend educational seminar series.
4th December 2018

Webinar: Demo at Your Desk Spraytec

In this demonstration, the Spraytec laser diffraction system will be used to measure a continuous and a pulsed spray. You...
4th December 2018

Webinar: A Simple Alternative to ICP-MS for Elemental Impurity Analysis

The introduction of USP and ICH Q3D requires the pharmaceutical industry to re-evaluate how elemental impurity (heavy metal) testing is...
4th December 2018

Webinar: Rheological Assessment of Particle Size on Cohesive Strength of Powders

There is a great need to understand the fundamental rheological properties of particles as they pertain to industry and the...
4th December 2018

Webinar: Using the ASD FieldSpec® for Monitoring the Mine Environment

Malvern has announced it will be hosting a webinar focusing on the ASD FieldSpec® instrument, how it can be used...
21st November 2018

Webinar: Co-crystals and Chemistry Characterisation Optimisation

Malvern Panalytical has announced that its partner Concept Life Sciences will be hosting a new webinar titled 'Pharmaceutical Co-crystals and...
20th November 2018

Webinar: Capillary Rheometry in the Fabrication of Polymer Scaffolds for Tissue Engineering

Malvern Panalytical has announced its new webinar, titled 'Capillary Rheometry in the Fabrication of Polymer Scaffolds for Tissue Engineering'.
16th November 2018

Webinar: Zetasizer Ultra and Pro Demo

Malvern Panalytical will be hosting a new webinar to provide a demo of the Zetasizer Ultra and Pro.
15th November 2018

Innovative Solutions for Elemental and Structural Analysis Event, Trenčín

Malvern Panalytical cordially invites you to attend a seminar held in Prague, Czech Republic.
14th November 2018

Webinar: Particle size and 21CFR Part 11

Malvern Panalytical will be hosting new webinar 'Particle Size and 21CFR Part 11 - Data Integrity with Your Mastersizer 3000'.
14th November 2018

Webinar: Determining Absolute Particle Concentration Using MADLS

Malvern Panalytical has announced new webinar 'Determining Absolute Particle Concentration Using MADLS'.
13th November 2018

Malvern Panalytical’s Solutions for Elemental and Structural Analysis

Malvern Panalytical cordially invites you to attend a seminar held in Prague, Czech Republic.
13th November 2018

Malvern Panalytical’s X’raydiate Jalandhar Symposium

Materials research has been instrumental towards a better quality of life. Without pushing the limits of science, we wouldn’t be...
10th November 2018

Webinar: Major Advancement in the Elemental Analysis of Metal Sulfides

Malvern Panalytical has announced its latest webinar, titled 'Major Advancement in the Elemental Analysis of Metal Sulfides'. 
8th November 2018

Malvern Panalytical’s X’raydiate Hyderabad Symposium

Malvern Panalytical has announced the dates of the X'raydiate Hyderabad Symposium.
7th November 2018

Malvern Panalytical’s X’raydiate Pune Event

Malvern Panalytical has announced the latest edition of the X'raydiate Pune symposium.
5th November 2018

Malvern Panalytical’s DLS Workshop in Nottingham, UK

Malvern Panalytical has announced a dynamic light scattering (DLS) workshop in Nottingham, UK.
2nd November 2018

Malvern Panalytical’s 11th OMA User Day

Malvern Panalytical is hosting a free user day on how various analytical techniques can be used for applications related to...
31st October 2018

Webinar: Using Rheology to Characterise Asphalt for Roofing Applications

Malvern Panalytical has announced a new webinar titled 'Using Rheology to Characterise Asphalt for Roofing Applications'.
31st October 2018

Malvern Panalytical’s Particle Size Masterclass Webinar

Malvern Panalytical has announced a new webinar: 'Particle Size Masterclass: Best Practice with Setting Your Particle Size Specifications'.
30th October 2018

Malvern Panalytical’s NanoSight Workshop in Edinburgh, UK

Malvern Panalytical has announced a NanoSight Workshop in Edinburgh, UK.
30th October 2018

DLS Workshop in Cambridge, UK

Malvern Panalytical has announced the dynamic light scattering (DLS) workshop in Cambridge, UK. 
21st October 2018

Webinar: ‘Particle Size Masterclass: How is Particle Size Measured?’

There is a gamut of particle size distribution measurement techniques each with established history and advantages. The killer word in...
16th October 2018

Analytical Approaches for Characterisation and Control Strategies

Malvern Panalytical has announced its latest webinar, 'Analytical Approaches and Regulatory Expectations for Characterisation and Control Strategies for Subvisible Particles...
11th October 2018

Accurate Analysis of Elemental Impurities According to USP <232>

The introduction of United States Pharmacopoeia (USP) and International Conference on Harmonisation (ICH) Q3D has required the pharmaceutical industry to...
10th October 2018

Analytical Tools to Accelerate Deformulation of OINDPs

For complex generic pharmaceutical products such as locally-acting nasal sprays, the US Food and Drug Administration's (FDA) guidance outlines methods...
9th October 2018

Webinar: Elemental Analysis of a Wide Range of Oxides

When daily operations require elemental analysis of a wide range of inorganic / geological samples, it is often cumbersome or...
5th October 2018

Webinar: Introduction to NIR, VNIR and a History of ASD

Malvern Panalytical has announced its October webinar introducing near-infrared (NIR) and visible-near-infrared (VNIR) spectroscopy and the history of ASD, a...
4th October 2018

Webinar: Analytical Tools to Accelerate Deformulation of OSD Products

Oral solid dose (OSD) formulations remain a dominant delivery method for pharmaceutical products, representing more than 60% of global pharmaceutical...
2nd October 2018

Webinar: ‘Higher Resolution Particle Sizing with MADLS’

In traditional dynamic light scattering (DLS) experiments, the scattered light is detected at a single angle and then auto-correlated to...
2nd October 2018

Webinar: ‘Particle Size Masterclass: Why Measure Particle Size?’

Malvern has announced a new webinar titled 'Particle Size Masterclass: Why Measure Particle Size?'.
2nd October 2018

Malvern Panalytical to Exhibit at Mine Entra, Zimbabwe

Malvern Panalytical has announced that it will be attending the Mining, Engineering & Transport Expo (Mine Entra) in Zimbabwe. 
2nd October 2018

Establishing an analytical toolkit for the optimization of Li-ion battery electrode manufacturing

The electrodes used in Li-ion batteries have a defining influence on their electrochemical performance and are typically manufactured by coating...
12th October 2017

Optimizing metal powders for additive manufacturing

Exploring the impact of particle morphology and powder flowability
12th October 2017

Measuring the rheology of thermoplastic polymer melts

Using rotational and capillary rheometry to characterize polymer melts
12th October 2017

Understanding and minimizing polycaprolactone degradation during processing using multi-detector GPC and rheology

Measuring degradation related changes in molecular weight and rheology during polycaprolactone processing
12th October 2017

Malvern: Molecular and bulk characterization of PLA and PLGA samples using multi-detector GPC and rheometry

Exploring the relationship between molecular characteristics and bulk rheological properties of biodegradable polymers
12th October 2017

Reviewing a Decade of Online Particle Sizing

Zementwerk Berlin GmbH & Co KG (Berlin, Germany) has been using Insitec on-line laser diffraction particle sizing (Malvern Instruments) systems...
22nd August 2017

Laser-diffraction particle sizing pays dividends for wet-process monitoring

In this article, we take a look at how, from the starting point of an appropriate wet sensor, laser diffraction...
22nd August 2017

Setting a benchmark: Using rheology to define the performance of personal care products

Products, quality is often defined by a range of functional and sensory attributes, some of which may be easily measured...
27th June 2017

Malvern Instruments Reveals how Combined DLS/Raman Provides New Molecular Insights of Complex Fluids

In particular, Malvern's article demonstrates the correlation between molecular changes (Raman Spectroscopy) and microstructural evolution of rheological properties (DLS, DLS-optical...
1st September 2016

New Tools for Biopharma Development Take Center Stage on the Malvern AAPS 2015 Booth

New tools from Malvern that answer to specific analytical challenges in biopharma development will take center stage at this year’s...
5th October 2015

Malvern Instruments Establishes new Biopharmaceutical Applications Laboratory in the Heart of San Diego’s Biotech Community

Malvern Instruments has established a new biopharmaceutical applications laboratory in the heart of San Diego’s biotechnology cluster. The new laboratory...
30th July 2015

Resolve Challenges, Find Solutions: Join Malvern for Expert Help on Protein Interaction Analysis with MicroCal PEAQ-ITC

At the 29th Annual Symposium of The Protein Society (22-25th July, Barcelona, Spain) Natalia Markova, Principal Scientist- MicroCal, Malvern Instruments,...
10th July 2015

Malvern Reveals New Advances in Interfacial Measurement Techniques

At upcoming events in the colloids conference calendar, physicists from Malvern instruments will reveal new advances in the measurement of...
26th May 2015

Malvern Puts the Spotlight on Cutting Edge Analytical Strategies at ISFRS 2015

At the 7th International Symposium on Food Rheology and Structure (7 – 10th June, Zurich, Switzerland), experts from Malvern Instruments...
12th May 2015

Malvern Instruments to Showcase an Expanding Rheological Toolkit at AERC 2015

At the 10th Annual European Rheology Conference (AERC) - Cité des Congrès, Nantes, France, 14-17 April 2015 - Malvern Instruments...
13th March 2015

Analytical Strategies That Support OSD Formulation: A new Whitepaper from Malvern Instruments

A new whitepaper from Malvern Instruments provides detailed guidance on the analytical technologies that help to accelerate oral solid dosage...
12th February 2015

Malvern’s new OMNISEC GPC/SEC Platform Brings Ground-Breaking Performance to the Analysis of Polymers, Proteins and other Macromolecules

A completely new gel permeation/size exclusion chromatography (GPC/SEC) platform from Malvern Instruments breaks new ground in delivering the high performance,...
29th January 2015

Malvern to Show new Analytical Systems at Pittcon 2015 and Present Five Educational Short Courses

As part of its rapidly expanding range of analytical tools for materials characterization, Malvern Instruments will showcase a new chromatography...
22nd January 2015

Accelerating Deformulation: A New Whitepaper from Malvern Instruments for Generic Tablet Development

A new whitepaper from Malvern Instruments on Oral Solid Dose (OSD) deformulation demonstrates how the analytical technique of Morphologically Directed...
13th January 2015

Malvern Zetasizer APS Delivers Unattended Protein Screening for Medicon Valley’s SARomics Biostructures

An automated dynamic light scattering system from Malvern Instruments has become established as an essential part of the analytical toolkit...
5th December 2014

New Malvern Application Note Shows Value of Nanoparticle Tracking Analysis in Exosome Studies

Malvern Instruments has published a new application note that examines the use of the company’s NanoSight Nanoparticle Tracking Analysis (NTA)...
26th November 2014

Malvern Instruments Zetasizer Nano Plays Key Role in Research to Develop 3D Cell Cultures

Researchers at the School of Engineering and Materials Science, Queen Mary University London (QMUL), are using a Malvern Instruments Zetasizer...
5th November 2014

Malvern exhibits MicroCal and NanoSight Brands Alongside New Mastersizer and Zetasizer Products at AAPS 2014

Company showcases rapidly growing portfolio of analytical solutions for pharma and biopharma applications.
27th October 2014

Malvern Manager Award Marks Almost Two Decades of Service on the Powtech Advisory Committee

For Malvern Instruments marketing manager Mrs Renate Hessemann, this year's Powtech exhibition in Nürnberg, Germany (30 Sep-2 Oct 2014), was...
22nd October 2014

Malvern Technology Delivers Its Reliability in Multi-Disciplinary Lab at Queen Mary University London

The cross-disciplinary capabilities of Malvern Instruments’ technology are being fully exploited at Queen Mary University London. The Zetasizer Nano, NanoSight...
11th September 2014

Malvern’s Dr Alan Rawle Talks TLAs in Plenary Lecture at Particulate Systems Analysis Conference

Dr Alan Rawle, applications manager for Malvern Instruments, will give a plenary lecture at Particulate Systems Analysis (PSA) 2014, organised...
27th August 2014

Malvern Specialists to Deliver Inaugural Short Course on Polymer Characterization at Interplas 2014

Experienced polymer specialists from Malvern Instruments will deliver a short course on polymer solution characterization at this year’s Interplas (The...
27th August 2014

Malvern Instruments Presents Novel Products, New Software and Extended Applications for Systems Addressing Complex Analytical Challenges

Powtech 2014 coincides with the third anniversary of the launch of the Mastersizer 3000 laser diffraction particle size analyzer from...
27th August 2014

Analytical Solutions from Malvern Instruments Support University of Wisconsin-Milwaukee Researchers in Understanding Environmental Effects of Nanomaterials

Researchers at The School of Freshwater Science, University of Wisconsin-Milwaukee, USA, are using NanoSight Nanoparticle Tracking Analysis (NTA) from Malvern...
27th August 2014

Malvern Instruments’ New Zetasizer Helix Combines Dynamic Light Scattering and Raman Spectroscopy for Advanced Protein Structure Analysis

The new Zetasizer Helix from Malvern Instruments is a powerful tool for early stage biopharmaceutical development that enables the detailed...
27th August 2014

New Software for Malvern’s NanoSight NTA Systems Improves User Experience and Enhances Performance

Malvern Instruments has launched NTA 3.0, a new version of the software that drives its NanoSight Nanoparticle Tracking Analysis (NTA)...
4th August 2014

Malvern Instruments’ Alan Rawle is Invited Speaker at Brian Scarlett Memorial Session at World Congress for Particle Technology

Dr Alan Rawle, applications manager for Malvern Instruments, has been invited to speak as part of the Brian Scarlett Memorial...
15th April 2014

Malvern Exhibits New Automated RealTime Milling System at Powtech

Malvern, Sturtevant and Schenck joint development offers unprecedented control of micronization processes, for optimal manufacturing efficiency.
12th August 2011

University of Melbourne Student Wins Malvern Poster Prize at UK Colloids

The winner of the Malvern Instruments £250 prize for the best student poster presented at the recent UK Colloids 2011...
28th July 2011

New Software for Malvern’s Morphologi G3 Puts Particles in a Different Light!

Malvern Instruments has released a new version of software for the company’s Morphologi G3 particle characterization system. This fully automated...
26th July 2011

Malvern’s Viscotek TDAmax “Warms the Heart” of an Academic Polymer Scientist

"Good value and excellent performance is a combination that will warm the heart of any academic polymer scientist,” said Professor...
21st July 2011

Malvern’s New Telephoto Lens Challenges the Limits of Real-Time Particle Size Measurement

The introduction of a new telephoto lens for Insitec laser diffraction process systems from Malvern Instruments enables the on-line measurement...
24th May 2011

‘Two in a Row’ as Malvern Instruments Wins Queen’s Award for Second Year in Succession

UK-based materials characterization company Malvern Instruments is celebrating winning the Queen’s Award for Enterprise in two successive years. Details of...
21st April 2011

Malvern Instruments Insitec system is integral to new Automated RealTime Milling System on Sturtevant Inc. booth #1827 at Interphex 2011

Following recent joint development, Malvern Instruments Insitec on-line particle size analyzer will be exhibited on the Sturtevant Inc. booth at...
15th April 2011

Malvern’s Upcoming Webinars for Process Engineers

A series of webinars aimed at those working in the processing environment will take place during April, May and September...
30th March 2011

Malvern Specialist Explores Real-Time Particle Size Analysis at EuroPACT 2011

Bernd Looser, applications specialist for process systems at Malvern Instruments, will discuss particle size analysis both as part of a...
21st February 2011

New Download on Malvern Website Offers Laser Diffraction Method Development Guidance

Recently published and now available for download on the Malvern Instruments website, 'Method development for laser diffraction particle size analysis,'...
20th February 2011

Malvern’s New SEC-LS Dual Integrated Detector is Dedicated to Proteins

Malvern Instruments has launched the Zetasizer µV with OmniFACE and OmniSEC, a new SEC-LS (size exclusion chromatography - light scattering)...
10th February 2011

And the Winner is…‘Basic Principles of Particle Size Analysis’ – Malvern’s Most Downloaded Document

Materials characterisation company Malvern Instruments is known for the breadth and accessibility of the educational offering on its website, from...
27th January 2011

Malvern Kinexus Installed in New GMP Testing Facility at NMI Reutlingen

Used for biomaterials characterisation in field of regenerative medicine.
24th January 2011

Particle and Molecular Characterisation Focus for Malvern Instruments Short Courses at Pittcon 2011

Malvern Instruments will run two one-day short courses as part of the established program at Pittcon 2011on 13-18 March 2011...
11th January 2011

Malvern Expert Reviews Protein Charge Measurement at PepTalk Conference

As a leading provider of solutions for protein characterisation, Malvern Instruments is taking an active role at the CHI's 10th...
20th December 2010

Malvern Instruments Experts Win Industry Poster Award at DDL21

This year's Drug Delivery to the Lungs conference (DDL21; 8-10 Dec 10; Edinburgh, Scotland), was a resounding success for Malvern...
15th December 2010

Malvern Link II Named as Breakthrough Product of the Year

Malvern Link II has been named by Processing magazine as one of its Breakthrough Products of the Year for 2010....
13th December 2010

‘Blogs Away’ for Malvern Instruments at www.materials-talks.com

With the launch of www.materials-talks.com the Malvern Instruments team have opened a new global channel through which they can share...
10th December 2010

Malvern Announces ‘Early Access’ Program for New Raman Capabilities

Malvern Instruments has announced an 'early access program' designed to introduce the benefits of combining automated particle size/shape analysis on...
1st December 2010

‘Driving Towards Manufacturing Excellence’ – A New White Paper from Malvern Instruments

Driving towards manufacturing excellence: Ten reasons to adopt on-line particle size analysis' is a new white paper from Malvern Instruments...
16th November 2010
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Malvern’s Video Explores: What Is Differential Scanning Calorimetry (DSC)?

Published on November 3, 2016

Watch Malvern’s Introduction to GPC in 30 minutes

Quick Contact Malvern Panalytical

Differential scanning calorimetry as a diagnostic tool for cancer patients

Blood serum is a source of cancer biomarkers. Tumour development is accompanied by a metabolic malfunction may result in altered...
22nd August 2017

The impact of electrode particle size and shape on battery slurry viscosity

Batteries are ubiquitous in modern life and our reliance on them has never been greater. Therefore, ensuring optimum battery performance...
22nd August 2017

GPC/SEC analysis of polymer branching

Using triple detection GPC/SEC to understand branching in polymers
27th June 2017

Concentration limits for zeta potential measurements in the Zetasizer Nano

Explains the concentration limits for successful zeta potential measurements to be made. A case study is used to illustrate the...
27th June 2017

The power of multi-detector SEC in the analysis of antibodies

How OMNISEC can measure antibody absolute MW independent of size and structural changes.
27th June 2017

Malvern Instruments: GPC/SEC Analysis of Polymer Degradation

Understanding the effects of processing a polymer on its molecular weight, molecular weight distribution, and solution viscosity are important to...
2nd May 2017

Malvern: How to use GPC/SEC for Compositional Analysis

Over the last century, as synthetic polymers became more prevalent, a desire arose to fine-tune the physical properties of these...
2nd May 2017

Malvern explores how Switching Mobile Phases can Improve your OMNISEC Results

Analysis of ester- and acid-capped PLGA samples in mobile phases of DCM and THF.
17th March 2017

Malvern: Multi-detector GPC/SEC analysis of polysaccharides using OMNISEC

How moving to multi-detector GPC can give greater insight than conventional measurements.
17th March 2017

Processing non-Newtonian products: Determining the pressure drop for a power law fluid along a straight circular pipe

In the chemical and process industries, it is often required to pump fluids over long distances from storage to various...
17th March 2017

MicroCal PEAQ-DSC Brochure

Biomolecular stability analysis for the regulated environment
21st February 2017

How investing in Malvern helped KBI Biopharma find a clear commercial advantage

Written by Dr. Amber Fradkin of KBI Biopharma, who manages the Particle Characterization Core Facility at KBI Biopharma in Boulder,...
2nd February 2017

Using Squeeze Flow to Extend Rheological Measurements for Concentrated Suspensions

Making shear rheological measurements on samples with a high solids fraction can present difficulties on a rotational rheometer, since the...
10th January 2017

Using Laser Diffraction to Characterize Casein Micelles and Fat Globules in Milk

To improve its shelf-life, milk undergoes a homogenization process. This process produces fat globules of a uniform, small size. During...
10th January 2017

Introducing Morphologically-Directed Raman Spectroscopy

A powerful tool for the detection of counterfeit drugs
10th January 2017

Time to Harness the True Power of Rheology

Upgrading from a viscometer to a modern rotational rheometer brings access to a range of test methods that can be...
10th January 2017

On the Same Wavelength: Calcium Carbonate Particle Size and Laser Technology

Malvern Instruments embarks on particle size analysis of carbon carbonates by utilising laser diffraction, a technique adopted for the use...
1st September 2016

A Thirst for Knowledge: Malvern Monitors Microfiltration Processes for Water Treatment

Malvern dives into quantifying nanoparticle concentration and size to optimize filtration processes
31st August 2016

The Dynamism of DSC in Membrane Behaviour

To reveal the basics of liposome sample preparation and DSC studies, Malvern Instruments uses this fundamental technique to characterize thermotropic...
31st August 2016

Characterisation of Protein-Protein Interactions Using SEC-TD

The ability of proteins to form ordered, structured complexes is central to their biological function.
8th April 2016

Comparing Rheology and Particle Size of Smoothies

Smoothies have been around for the best part of a century. However, it was not until the development, commercialisation and...
8th April 2016

Evaluating Product Spreading Characteristics on Rotational Rheometers

The rheological properties of a product can influence how it is visually and texturally perceived by a consumer and how...
8th April 2016

Analysis of Demicellisation Data from Isothermal Titration Calorimetry

Many industrial and biochemical applications depend on the use of detergents and other surfactants.
3rd November 2015

Optimising Fluid Rheology for EOR Applications

In this case study, Malvern Panalytical presents elements of the work carried out by Rafael Hincapie as part of his...
3rd November 2015

Characterisation of IgG Monomers and their Aggregates

In biopharmaceutical formulations, one of the key factors that manufacturers need to understand is the propensity of their samples to...
3rd November 2015

Optimisation of PLA/PLGA Molecular Weight and Structure

Biodegradable and biocompatible polymers polylactic acid (PLA) and polylactic-co-glycolic acid (PLGA) are used in many different applications, including food packaging,...
3rd November 2015

Differentiation of Polymer Branching and Composition

In this application note, Malvern Panalytical will show how to separate the effects of a structural difference induced by a...
3rd November 2015
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