Tosoh Bioscience - Pharmaceutical Business review - Specialist Separation Solutions

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WHITE PAPERS

Alternate Selectivity for Polar Compounds in Hydrophilic Interaction Liquid Chromatography (HILIC) Using a New Amino Type HILIC Column

Analysis of cationic polymers by Size Exclusion Chromatography with TSK-GEL®

Analysis of Melamine and Cyanuric Acid in Milk by LC-MS/MS

Analysis of Saccharides by HILIC using TSKgel® NH2-100 Columns

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PRODUCTS & SERVICES

SEC/GPC Instruments

HPLC Columns

Preparative and Process Chromatography

Multi-Column Chromatography

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LATEST PRESS RELEASES

November 11, 2024

Tosoh Bioscience – Separation & Purification Expands European Headquarters in Griesheim, Germany

Tosoh Bioscience – Separation & Purification has announced the grand opening of its expanded European Tosoh Bioscience headquarters in Griesheim,...

October 29, 2024

BioSeparation Sustainable Biochromatography Forum ‒ Join Us in Vienna on 27 November 2024

Are you involved in the production or characterisation of biomolecules? Then the BioSeparation Forum at Vienna University, taking place from...

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Tosoh Bioscience

Tosoh Bioscience is an acknowledged global leader in the field of liquid chromatography with a strong focus on bioseparations. We offer solutions for research, drug discovery, clinical chemistry, environmental analysis, manufacturing and other industrial applications.

Tosoh’s portfolio of more than speciality products encompasses a comprehensive line of chromatographic media, high-performance liquid chromatography (HPLC) columns, and gel permeation chromatography (GPC) instruments.

We can help to analyse and purify any protein, peptide, nucleic acid, antibiotic or small molecule.

Based on existing resins, we are also able to develop customised products.

Tosoh Bioscience is the sole sponsor of the conference on Hydrophobic Interaction and Reversed Phase Chromatography (HIC/RPC Bioseparation Conference).

Research for the biopharmaceutical market

Tosoh Bioscience provides research and production of biopharmaceuticals for research institutes, university laboratories and routine laboratories for chemical, biochemical and environmental analysis.

Products for liquid chromotography

Tosoh Bioscience offers a comprehensive line of media and pre-packed columns for all common modes of liquid chromatography, including ion exchange, hydrophobic interaction, reversed phase, size exclusion and affinity.

Toyopearl® and TSKgel® chromatographic resins and columns are renowned for their quality and reliability. In addition to chromatographic resins and columns, Tosoh Bioscience manufactures instruments for GPC.

Services and facilities

Tosoh Bioscience’s European operations are headquartered in Griesheim, Darmstadt, and offer technical service by phone, e-mail or on-site.

This service includes troubleshooting, applications for analytical and research and development (R&D) scientists, method development and scale up, as well as on-site large-column packing support.

Tosoh’s manufacturing sites in Japan provide products to the sales and support subsidiaries in the USA, Europe and China, ensuring full global coverage.

Chromatographic techniques

Tosoh uses a wide variety of chromatographic techniques, including:

• HPLC, ultra-high-performance liquid chromatography (UHPLC) and liquid chromatography-mass spectroscopy ( LC-MS)

• Ion exchange chromatography (IEC)

• Hydrophobic interaction chromatography (HIC)

• Reversed phase chromatography (RPC)

• Hydrophilic interaction chromatography (HILIC)

• Size exclusion chromatography (SEC) and high-pressure size exclusion chromatography (HPSEC)

• Gel permeation chromatography (GPC)

• Affinity chromatography

• Preparative and process chromatography

Contact details:
Tosoh Bioscience GmbH
Im Leuschnerpark 4
64347 Griesheim
Germany
Tel: +49 6155-7043700
Fax: +49 6155-8357900
info.tbg@tosoh.com
www.tosohbioscience.de

SEC/GPC Instruments

Based on a long history of producing GPC/SEC systems for the Asian market, Tosoh developed the EcoSEC system to meet the market needs for high resolution, semi micro GPC. EcoSEC is a compact, all-in-one GPC system.

It offers outstanding performance and short analysis time when combined with semi-micro columns. Semi-micro GPC saves solvent, sample amount, analysis time and waste disposal costs.

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BROCHURE AVAILABLE

HPLC Columns

TSKgel® stationary phases are available as porous or non-porous, silica or polymeric particles (2-10 µm) in HPLC columns for micro-bore, analytical or preparative use.

The development of the first TSKgel GPC column in 1971 had set the course for a long and proud history of size exclusion chromatography (SEC) at Tosoh. Today, the range of SEC related products comprises of SEC/GPC systems and stationary phases for both modes of size exclusion chromatography, aqueous gel filtration (GFC) and organic gel…

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Preparative and Process Chromatography

TOYOPEARL® and TSKgel® resins are based on a semi rigid, hydrophilic, macroporous particle. Their rigid backbone has better pressure-flow properties than most other commercially made materials.

Therefore, higher linear operating velocities can be used for faster process throughput and decreased recycling times. TOYOPEARL resins are stable over the pH 2-12 range for normal operating conditions and pH 1-13 for cleaning conditions. They are available in average particle sizes of 35, 65, 75, and 100 µm for high resolution, intermediate purification, or…

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Multi-Column Chromatography

Multi-column chromatography (MCC) is a method of downstream processing designed for purifying biological targets. MCC can be run continuously and intensifies the chromatography step by the operating multiple small columns in parallel. This substantially increases process productivity (g of product/L resin/hr), often by as much as 200%.

Tosoh offers two MCC hardware solutions, namely the Octave BIO System and the Octave PRO System. We also provide SkillPakTM pre-packed columns to enable seamless scale-up from development to production; these columns are designed to accommodate the faster flowrates of MCC, making them reliable and economical for biomolecule purification. The Octave™ BIO is a comprehensive,…

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BROCHURE AVAILABLE

Separation of Full and Empty AAV Capsids by Anionexchange Chromatography Using Choline-Type Salts

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Tosoh Bioscience

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Tosoh Bioscience

Research for the biopharmaceutical market

Products for liquid chromotography

Services and facilities

Chromatographic techniques

Top Products from Tosoh Bioscience

Based on a long history of producing GPC/SEC systems for the Asian market, Tosoh developed the EcoSEC system to meet the market needs for high resolution, semi micro GPC. EcoSEC is a compact, all-in-one GPC system.

TSKgel® stationary phases are available as porous or non-porous, silica or polymeric particles (2-10 µm) in HPLC columns for micro-bore, analytical or preparative use.

TOYOPEARL® and TSKgel® resins are based on a semi rigid, hydrophilic, macroporous particle. Their rigid backbone has better pressure-flow properties than most other commercially made materials.

Separation of Full and Empty AAV Capsids by Anionexchange Chromatography Using Choline-Type Salts

Development of clinically desirable adeno-associated virus (AAV) vectors with optimal genome design requires rapid and accurate analytical methods to assess AAV quality.

Antibody Capture and Analysis

Tosoh's purification resins and analysis columns have a long set standard in industrial manufacturing of biotherapeutics. Sustained investment in research and development (R&D) maintains the company's position at the technological frontier.

Oligonucleotide Purification and Analysis

The oligonucleotide therapeutics field has seen remarkable progress over the last few years. The first antisense drug was approved and clinical trials using small interfering ribonucleic acid (siRNA) or splice switching oligonucleotide show promising developments.

Smart HPLC Solutions for Large Molecules

TOYOPEARL gigaCap® Series

TOyOPEARl® AF-rProtein A-650F

Direct analysis of biogenic amines in food by HILIC-MS

Biogenic amines are present in protein-rich food such as fish, meat or milk. Their concentration increases during food decomposition. The reasons to monitor biogenic amines in food products are to determine that the food is suitable for consumption and to establish appropriate storage conditions.

Efficient SEC-UV-RI-MALS Analysis of Protein Aggregates

Analysis of Saccharides by HILIC using TSKgel® NH2-100 Columns

Saccharides are fundametal substances that express various bioactivities and may exist independently or form complexes with proteins or lipids. They can be classified into monosaccharides, disaccharides, oligosaccharides, polysaccharides, based upon the degrees of polymerization and condensation.

Analysis of Water-Soluble Polymers Using Linear Size Exclusion HPLC Columns and a Semi-Micro SEC System

CHARACTERIZING BIOTHERAPEUTICS WITH HPLC

Development and production of biopharmaceuticals is a growing segment of pharmaceutical industry. Therapeutic proteins include blood factors, thrombolytic agents, growth factors, interferons, interleukins, therapeutic enzymes and last but not least monoclonal antibodies.

Reversed-Phase Analysis of Alkylbenzene Sulfonates

Characterisation Studies of PEGylated Lysozyme

Glycosylation analysis by hydrophilic interaction chromatography (HILIC) – N-Glyco mapping of the ZP-domain of murine TGFR-3

Alternate Selectivity for Polar Compounds in Hydrophilic Interaction Liquid Chromatography (HILIC) Using a New Amino Type HILIC Column

Analysis of Melamine and Cyanuric Acid in Milk by LC-MS/MS

HPLC Analysis of lysozyme in different types of wine

Analysis of cationic polymers by Size Exclusion Chromatography with TSK-GEL®

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