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WHITE PAPERS
Alternate Selectivity for Polar Compounds in Hydrophilic Interaction Liquid Chromatography (HILIC) Using a New Amino Type HILIC Column
Analysis of cationic polymers by Size Exclusion Chromatography with TSK-GEL®
Analysis of Melamine and Cyanuric Acid in Milk by LC-MS/MS
Analysis of Saccharides by HILIC using TSKgel® NH2-100 Columns
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PRODUCTS & SERVICES
SEC/GPC Instruments
HPLC Columns
Preparative and Process Chromatography
Multi-Column Chromatography
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LATEST PRESS RELEASES
June 17, 2024

Tosoh Bioscience and the University of Applied Sciences Mittelhessen Announce Partnership in Continuous Purification of Viruses and Viral Vectors

Tosoh Bioscience, a leading provider of chromatographic solutions for biomolecule separation and purification, announced a pioneering partnership with Prof Dr...
pharmacuetical business review
November 3, 2023

Safety First: Tosoh Bioscience Transforms Gene Therapy with Innovative AAV Analysis Technique

Tosoh Bioscience, a renowned leader in the field of chromatography, announced the recent publication of a groundbreaking paper titled 'Separation...
pharmacuetical business review
View all Press Releases


LATEST VIDEOS

Tosoh Bioscience

Tosoh Bioscience is an acknowledged global leader in the field of liquid chromatography with a strong focus on bioseparations. We offer solutions for research, drug discovery, clinical chemistry, environmental analysis, manufacturing and other industrial applications.

Tosoh’s portfolio of more than speciality products encompasses a comprehensive line of chromatographic media, high-performance liquid chromatography (HPLC) columns, and gel permeation chromatography (GPC) instruments.

We can help to analyse and purify any protein, peptide, nucleic acid, antibiotic or small molecule.

Based on existing resins, we are also able to develop customised products.

Tosoh Bioscience is the sole sponsor of the conference on Hydrophobic Interaction and Reversed Phase Chromatography (HIC/RPC Bioseparation Conference).

Research for the biopharmaceutical market

Tosoh Bioscience provides research and production of biopharmaceuticals for research institutes, university laboratories and routine laboratories for chemical, biochemical and environmental analysis.

Products for liquid chromotography

Tosoh Bioscience offers a comprehensive line of media and pre-packed columns for all common modes of liquid chromatography, including ion exchange, hydrophobic interaction, reversed phase, size exclusion and affinity.

Toyopearl® and TSKgel® chromatographic resins and columns are renowned for their quality and reliability. In addition to chromatographic resins and columns, Tosoh Bioscience manufactures instruments for GPC.

Services and facilities

Tosoh Bioscience’s European operations are headquartered in Griesheim, Darmstadt, and offer technical service by phone, e-mail or on-site.

This service includes troubleshooting, applications for analytical and research and development (R&D) scientists, method development and scale up, as well as on-site large-column packing support.

Tosoh’s manufacturing sites in Japan provide products to the sales and support subsidiaries in the USA, Europe and China, ensuring full global coverage.

Chromatographic techniques

Tosoh uses a wide variety of chromatographic techniques, including:

•  HPLC, ultra-high-performance liquid chromatography (UHPLC) and liquid chromatography-mass spectroscopy ( LC-MS)

•  Ion exchange chromatography (IEC)

•  Hydrophobic interaction chromatography (HIC)

•  Reversed phase chromatography (RPC)

•  Hydrophilic interaction chromatography (HILIC)

•  Size exclusion chromatography (SEC) and high-pressure size exclusion chromatography (HPSEC)

•  Gel permeation chromatography (GPC)

•  Affinity chromatography

•  Preparative and process chromatography

Contact details:
Tosoh Bioscience GmbH
Im Leuschnerpark 4
64347 Griesheim
Germany
Tel: +49 6155-7043700
Fax: +49 6155-8357900
info.tbg@tosoh.com
www.tosohbioscience.de

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Top Products from Tosoh Bioscience


Multi-Column Chromatography

SEC/GPC Instruments

Preparative and Process Chromatography
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SEC/GPC Instruments

Based on a long history of producing GPC/SEC systems for the Asian market, Tosoh developed the EcoSEC system to meet the market needs for high resolution, semi micro GPC. EcoSEC is a compact, all-in-one GPC system.

It offers outstanding performance and short analysis time when combined with semi-micro columns. Semi-micro GPC saves solvent, sample amount, analysis time and waste disposal costs.
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HPLC Columns

TSKgel® stationary phases are available as porous or non-porous, silica or polymeric particles (2-10 µm) in HPLC columns for micro-bore, analytical or preparative use.

The development of the first TSKgel GPC column in 1971 had set the course for a long and proud history of size exclusion chromatography (SEC) at Tosoh. Today, the range of SEC related products comprises of SEC/GPC systems and stationary phases for both modes of size exclusion chromatography, aqueous gel filtration (GFC) and organic gel…
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Preparative and Process Chromatography

TOYOPEARL® and TSKgel® resins are based on a semi rigid, hydrophilic, macroporous particle. Their rigid backbone has better pressure-flow properties than most other commercially made materials.

Therefore, higher linear operating velocities can be used for faster process throughput and decreased recycling times. TOYOPEARL resins are stable over the pH 2-12 range for normal operating conditions and pH 1-13 for cleaning conditions. They are available in average particle sizes of 35, 65, 75, and 100 µm for high resolution, intermediate purification, or…
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Multi-Column Chromatography

Multi-column chromatography (MCC) is a method of downstream processing designed for purifying biological targets. MCC can be run continuously and intensifies the chromatography step by the operating multiple small columns in parallel. This substantially increases process productivity (g of product/L resin/hr), often by as much as 200%.

Tosoh offers two MCC hardware solutions, namely the Octave BIO System and the Octave PRO System. We also provide SkillPakTM pre-packed columns to enable seamless scale-up from development to production; these columns are designed to accommodate the faster flowrates of MCC, making them reliable and economical for biomolecule purification. The Octave™ BIO is a comprehensive,…
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Separation of Full and Empty AAV Capsids by Anionexchange Chromatography Using Choline-Type Salts

Separation of Full and Empty AAV Capsids by Anionexchange Chromatography Using Choline-Type Salts

Development of clinically desirable adeno-associated virus (AAV) vectors with optimal genome design requires rapid and accurate analytical methods to assess AAV quality.

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Antibody Capture and Analysis

Antibody Capture and Analysis

Tosoh's purification resins and analysis columns have a long set standard in industrial manufacturing of biotherapeutics. Sustained investment in research and development (R&D) maintains the company's position at the technological frontier.

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Oligonucleotide Purification and Analysis

Oligonucleotide Purification and Analysis

The oligonucleotide therapeutics field has seen remarkable progress over the last few years. The first antisense drug was approved and clinical trials using small interfering ribonucleic acid (siRNA) or splice switching oligonucleotide show promising developments.

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Smart HPLC Solutions for Large Molecules

Smart HPLC Solutions for Large Molecules

The biopharmaceutical research sector and its products represent a significant area of growth for today’s pharmaceutical industry. Major biotherapeutic categories currently include vaccines, therapeutic proteins such as growth factors or cytokines, and, last but not least, monoclonal antibodies. A thorough characterisation of these products is a key task for the successful submission of data for their regulatory approval.

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TOYOPEARL gigaCap® Series

TOYOPEARL gigaCap® Series

ion exchange Chromatography (iEC) is one of the most frequently used chromatographic modes for the separation and purifi cation of biomolecules. it is used at all stages and scales of purifi cation of therapeutic proteins: from laboratory scale purifi cation to industrial scale downstream processing (dSP). toyopearl media are hydrophilic, macroporous polymethacrylate resins, available with various ligands and in different particle and pore sizes.

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TOyOPEARl® AF-rProtein A-650F

TOyOPEARl® AF-rProtein A-650F

Protein A based affi nity chromatography is the industry standard for the capture of monoclonal antibodies (MAbs) in downstream processing. Affi nity media offer high selectivity thereby yielding a high purity of the target molecule in one step. The antibodies are captured at near neutral pH and eluted using acidic pH. The rising fermentation titres in the production of monoclonal antibodies drive the focus on developing resins that increase downstream capacity and effi ciency for these processes.

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Direct analysis of biogenic amines in food by HILIC-MS

Direct analysis of biogenic amines in food by HILIC-MS

Biogenic amines are present in protein-rich food such as fish, meat or milk. Their concentration increases during food decomposition. The reasons to monitor biogenic amines in food products are to determine that the food is suitable for consumption and to establish appropriate storage conditions.

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Efficient SEC-UV-RI-MALS Analysis of Protein Aggregates

Efficient SEC-UV-RI-MALS Analysis of Protein Aggregates

Static light scattering in combination with size exclusion chromatography is a valuable tool for verifying purity of monoclonal antibodies (MABS) as such or as a quick check while the downstream processing takes place. Besides fluorescence detection, light scattering is one of the most sensitive methods to detect protein aggregates.

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Analysis of Saccharides by HILIC using TSKgel® NH2-100 Columns

Analysis of Saccharides by HILIC using TSKgel® NH2-100 Columns

Saccharides are fundametal substances that express various bioactivities and may exist independently or form complexes with proteins or lipids. They can be classified into monosaccharides, disaccharides, oligosaccharides, polysaccharides, based upon the degrees of polymerization and condensation.

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Analysis of Water-Soluble Polymers Using Linear Size Exclusion HPLC Columns and a Semi-Micro SEC System

Analysis of Water-Soluble Polymers Using Linear Size Exclusion HPLC Columns and a Semi-Micro SEC System

In recent years water-soluble polymers are gaining more and more interest in different applications. The molecular weight distribution of polymers is usually characterized by size exclusion chromatography (SEC) coupled with refractive index, viscometric or laser light scattering detection. Recent advances in SEC comprise semi-micro SEC and the design of linear columns providing wide molecular weight separation ranges and near-linear calibrations.

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CHARACTERIZING BIOTHERAPEUTICS WITH HPLC

CHARACTERIZING BIOTHERAPEUTICS WITH HPLC

Development and production of biopharmaceuticals is a growing segment of pharmaceutical industry. Therapeutic proteins include blood factors, thrombolytic agents, growth factors, interferons, interleukins, therapeutic enzymes and last but not least monoclonal antibodies.

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Reversed-Phase Analysis of Alkylbenzene Sulfonates

Reversed-Phase Analysis of Alkylbenzene Sulfonates

Linear alkylbenzene sulfonates (LASs) are synthetic surfactants, which are produced by alkylation and sulfonation of benzene. LASs are a mixture of homologues and phenyl positional isomers, each containing an aromatic ring sulfonated at the para position and attached to a linear alkyl chain. The product is used in detergents and cleaning products for domestic and industrial use.

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Characterisation Studies of PEGylated Lysozyme

Characterisation Studies of PEGylated Lysozyme

PEGylation, the process by which polyethylene glycol (PEG) chains are attached to protein and peptide drugs is a common practice in the development of biopharmaceuticals to prolong serum half-life and improve pharmacokinetics of a drug. There is increasing demand for chromatographic methods to separate the modified isoforms from the native protein.

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Glycosylation analysis by hydrophilic interaction chromatography (HILIC) – N-Glyco mapping of the ZP-domain of murine TGFR-3

Glycosylation analysis by hydrophilic interaction chromatography (HILIC) – N-Glyco mapping of the ZP-domain of murine TGFR-3

Glycosylation is one of the most common forms of post-translational modification of eukaryotic proteins. Glycosylated proteins (glycoproteins) make up the majority of human proteins. The polysaccharide side chains (Glycans) play critical roles in physiological and pathological reactions ranging from immunity to cell signaling, development and death.

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Alternate Selectivity for Polar Compounds in Hydrophilic Interaction Liquid Chromatography (HILIC) Using a New Amino Type HILIC Column

Alternate Selectivity for Polar Compounds in Hydrophilic Interaction Liquid Chromatography (HILIC) Using a New Amino Type HILIC Column

Hydrophilic interaction liquid chromatography (HILIC) offers unique advantages for the separation of very polar compounds when compared to reversed-phase chromatography. A new silica based HILIC phase was developed to provide additional selectivity options in HILIC separations. The separation of water soluble vitamins on the new TSKgel NH2-100 HILIC column and on the well known TSKgel Amide-80 HILIC column demonstrates the differences in selectivity.

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Analysis of Melamine and Cyanuric Acid in Milk by LC-MS/MS

Analysis of Melamine and Cyanuric Acid in Milk by LC-MS/MS

Melamine is an organic base and a trimer of cyanamide, with a 1,3,5-triazine skeleton. Melamine is combined with formaldehyde to produce melamine resin, a very durable thermosetting plastic, and melamine foam, a polymeric cleaning product. The end products include countertops, dry erase boards, fabrics, glues, house wares and flame retardants. Melamine is one of the major components in Pigment Yellow 150, a colorant in inks and plastics.

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HPLC Analysis of lysozyme in different types of wine

HPLC Analysis of lysozyme in different types of wine

Hen’s egg white lysozyme is used in winemaking to eliminate lactic acid bacteria and to control malolactic fermentation. As eggs and derivatives are regarded as potential allergenics the European Commission issued a directive that wine labels must include information about egg derived ingredients like lysozyme. As a consequence the International Organisation for Wine and Vine (OIV) published a standard method for measurement of lysozyme in wine by HPLC, which is based on a method developed at the University of Bologna.

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Analysis of cationic polymers by Size Exclusion Chromatography with TSK-GEL®

Analysis of cationic polymers by Size Exclusion Chromatography with TSK-GEL®

In recent years water soluble cationic polymers are gaining more and more interest in different applications ranging from hair conditioning to gene transfection and drug delivery. The molecular weight distribution of polymers is usually characterized by SEC coupled with refractive index, viscometric or laser light scattering detection.

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Tosoh Bioscience and the University of Applied Sciences Mittelhessen Announce Partnership in Continuous Purification of Viruses and Viral Vectors

Tosoh Bioscience, a leading provider of chromatographic solutions for biomolecule separation and purification, announced a pioneering partnership with Prof Dr...
17th June 2024

Safety First: Tosoh Bioscience Transforms Gene Therapy with Innovative AAV Analysis Technique

Tosoh Bioscience, a renowned leader in the field of chromatography, announced the recent publication of a groundbreaking paper titled 'Separation...
3rd November 2023

Tosoh at the BioProcess International Conference ‒ 19-21 September in Boston, MA

Tosoh Bioscience, a leading company in the field of liquid chromatography, is currently at the BioProcess International (BPI) conference in...
20th September 2023

Tosoh Bioscience Launches Its Holistic Multi-Column Chromatography Solution for Downstream Process Intensification

New Octave® chromatography systems and dedicated SkillPakTM pre-packed columns
28th September 2022

Tosoh to Increase Production Capacity of Separation and Purification Media

Tosoh Corporation has announced it will increase the production capacity of separation and purification media TOYOPEARL®and TSKgel® PW at its...
9th August 2022

Tosoh Bioscience Introduces TSKgel® UP-SW3000-LS UHPLC Columns

Superior performance in advanced detection methods such as MALS and MS
25th May 2022

UGA Biopharma Partners with Tosoh Bioscience on Cell Line and USP Technology Transfer to Generate New DSP Knowledge

17th December 2021

Tosoh Bioscience Completes the Acquisition of Semba Biosciences

22nd October 2021

Tosoh Bioscience Celebrates 50th Anniversary of the TSKgel® Column Brand

6th September 2021

Tosoh Bioscience Introduces TSKgel® FcR-IIIA-5PW HPLC Column

Fraction Collection of Antibodies with Different FcR Affinities for Characterization.
19th April 2021

Tosoh Biosience to Hold Virtual BioSeparation Forum

Gain insights into chromatography, new therapies, and antibody manufacturing & characterization.
30th September 2020

Novel Coronavirus Antibody Detection Reagent in Development at Tosoh

10th June 2020

Tosoh Bioscience Introduces SkillPak™ Pre-packed Columns

A new process development tool now available.
2nd April 2020

Tosoh Pursues Development of a New Coronavirus Test Kit Utilizing the Transcription-Reverse Transcription Concerted (TRC) reaction method

21st February 2020

30 Years One-Stop-Shop for Protein Purification and Analysis

Tosoh Bioscience celebrates 30 years of operation in Germany.
6th December 2019

Tosoh Announces Two New Application Notebooks

Tosoh is pleased to announce the launch of two new application notebooks.
18th September 2019

Tosoh Bioscience Introduces TSKgel® FcR-IIIA-NPR Columns

Tosoh Bioscience has introduced its TSKgel FcR-IIIA-NPR high-performance liquid chromatography (HPLC) column.
1st March 2019

Tosoh Bioscience Releases New Hydroxyapatite with Ca++Pure-HA

Tosoh Bioscience has introduced a new hydroxyapatite medium to its product portfolio.
11th October 2018

Tosoh Bioscience: New High Capacity TOYOPEARL® rProtein L Resin

High capacity chromatography resin for the capture of antibodies and antibody fragments.
31st July 2017

Tosoh Bioscience: Broad Dynamic Range for Fast Antibody Titer Analysis

TSKgel Protein A-5PW supports high throughput screening by fast analysis.
31st July 2017

TSKgel Size Exclusion Columns for UHPLC

Increased throughput and resolution for SEC analysis
15th November 2016

TOYOPEARL Sulfate-650F – The Smart Cation Exchange Resin

Salt tolerant cation exchanger with high IgG capacity
15th November 2016

Tosoh to Increase Production Capacity of Toyopearl Liquid Chromatography Separation and Purification Media

Tokyo, Japan —Tosoh Corporation has announced that it will be increasing the production capacity of its Toyopearl liquid chromatography separation...
24th October 2016

New Ultra-High Capacity TOYOPEARL® Protein A Resin

High capacity chromatography resin for the capture and purification of monoclonal antibodies.
16th December 2013

TSKgel mAb SEC Columns – Setting new Benchmarks for Antibody Analysis

TSKgel SW size exclusion columns - the industry's workhorse for aggregate analysis - continue to set standards for the UHPLC...
5th June 2013

TSKgel Protein C4-300: Speed and Resolution for Proteins Analysis

Tosoh Bioscience introduces a new reversed phase HPLC column for the separation of intact proteins. TSKgel Protein C4-300 consists of...
27th March 2012
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